Analysis of the mechanism of gastric inflammation caused by Helicobacter pylori infection and development of alternative medicine

幽门螺杆菌感染引起胃炎症的机制分析及替代医学的发展

• 批准号: 19590696
• 负责人: KITA Masakazu
• 金额: $ 2.33万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590696/
• 关键词: ヘリコバクター; サイトカイン; 耐性菌; 漢方薬; 代替療法

Helicobacter pylori (H.pylori) is the major cause of chronic active gastritis and peptic ulcer disease. Although it is suspected that cytokines are involved in gastric inflammation induced by H.pylori, the mechanisms have not been clearly defined. In this study, the contributions of IL-17 to the induction of gastric inflammation and to the protection from H.pylori infection were investigated using IL-17 gene-knockout (IL-17^<-/->) mice. Our results suggest that IL-17 may play an important role in the inflammatory response to the H.pylori infection and ultimately influence the outcome of the H.pylori associated disease. On the other hand, the antibacterial effect of 18 herbal medicines was evaluated in vitro and in vivo. Rhei Rhizoma, Artemisiae Capillari Flos and Caryophylli Flos were bactericidal against H.pylori without the development of acquired resistance, suggesting that herbal medicines may have potential as complementary and alternative medicines for treatment of antibiotic-resistant H. pylori infection.

幽门螺杆菌(Hp)是引起慢性活动性胃炎和消化性溃疡的主要原因。尽管有人怀疑细胞因子参与了幽门螺杆菌引起的胃炎症，但其机制尚不清楚。本研究利用IL-17基因敲除小鼠(IL-17^&lt；-/-&gt；)，研究了IL-17在诱导胃炎症和保护幽门螺杆菌感染中的作用。我们的结果提示IL-17可能在幽门螺杆菌感染的炎症反应中发挥重要作用，并最终影响幽门螺杆菌相关性疾病的转归。另一方面，对18种中草药的体内外抗菌作用进行了评价。大黄、青蒿花和石竹花对幽门螺杆菌有杀菌作用，但不产生获得性耐药性，提示中草药有可能作为治疗耐药幽门螺杆菌感染的补充和替代药物。

项目成果

Helicobacter pylori感染症におけるIL-17Aの関与

IL-17A参与幽门螺杆菌感染

• 发表时间: 2009
• 作者: 喜多正和;塩見聡;今西二郎
• 通讯作者: 今西二郎

Helicobacter pylori感染により発症する胃炎におけるIL-17の役割

IL-17在幽门螺杆菌感染胃炎中的作用

• 发表时间: 2007
• 作者: 喜多正和;塩見聡;今西二郎
• 通讯作者: 今西二郎

Levels of interleukin-18 are markedly increased in Helicobacter pylori-Infected gastric mucosa among patients with specific IL18 genotypes

• DOI: 10.1086/588196
• 发表时间: 2008-06-15
• 期刊: JOURNAL OF INFECTIOUS DISEASES
• 影响因子: 6.4
• 作者: Sakai, Kyoko;Kita, Masakazu;Yamaoka, Yoshio
• 通讯作者: Yamaoka, Yoshio

ヘリコバクターピロリ誘発胃炎マウスモデルにおけるIL-17の役割

IL-17在幽门螺杆菌诱导的胃炎小鼠模型中的作用

• 发表时间: 2008
• 作者: 喜多正和;塩見聡;今西二郎
• 通讯作者: 今西二郎

Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains

• DOI: 10.1074/jbc.m611178200
• 发表时间: 2007-03-02
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Lu, Hong;Wu, Jeng Yih;Yamaoka, Yoshio
• 通讯作者: Yamaoka, Yoshio