Alternative therapies for antibiotic-resistant Helicobacter pylori infection
Alternative therapies for antibiotic-resistant Helicobacter pylori infection
批准号:
23590890
负责人:
KITA Masakazu
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
Helicobacter pylori (H. pylori) infection is highly associated with the occurrence of gastrointestinal diseases, including gastric inflammation, peptic ulcer and gastric cancer. The standard triple therapy consisting of PPI and two antibiotics is widely used as the regimen for treatment of infection, but the increased resistance of H. pylori to clarithromycin and metronidazole has significantly reduced the eradication rate. In this study, the antimicrobial effect of 18 herbal medicines was evaluated in vitro and in vivo. Several herbal medicines inhibited the growth of antibiotic-resistant strains of H. pylori at a dose of 1 mg/ml in vitro. On the other hand, the density of H. pylori in the stomach of mice treated with 3 herbal medicines (Coptidis Rhizoma, Glycyrrhizae Radix and Caryophylli Flos) was significantly reduced. These results suggest that herbal medicines may have potential as complementary and alternative medicines for treatment of antibiotic-resistant H. pylori infection.
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DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[喜多正和, 酉家章弘, 今西二郎]
通讯作者:
今西二郎
薬剤耐性H. pylori感染に対する生薬の抗菌効果
草药对耐药幽门螺杆菌感染的抗菌作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[喜多正和, 酉家章弘, 今西二郎]
通讯作者:
今西二郎
クラリスロマイシン耐性ヘリコハクター・ヒロリ感染症に対する生薬の抗菌効果
生药对克拉霉素耐药广螺杆菌感染的抗菌作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[喜多正和, 酉家章弘, 今西二郎]
通讯作者:
今西二郎
ヘリコバクター感染症モデル(分担)、疾患モデルの作製と利用「糖尿病・肥満/感染症」
螺杆菌感染模型(共享)、疾病模型“糖尿病/肥胖/传染病”的制作与使用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[石川剛, 古倉聡, 坂元直行, 他, 喜多正和]
通讯作者:
喜多正和
H. pylori感染症に対する生薬の治療効果
草药对幽门螺杆菌感染的治疗作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[喜多正和, 酉家章弘, 今西二郎]
通讯作者:
今西二郎
共 9 条
Learner-centered Lesson Development with Teaching Assumptions by using Japanese Style as a model
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批准号:16K00965
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2016
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Establishment of the network on natural environmental education by collaboration among schools in Japan, Africa, and Asia
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批准号:20300257
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资助金额:$11.9万
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财政年份:2008
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依托单位:
Analysis of the mechanism of gastric inflammation caused by Helicobacter pylori infection and development of alternative medicine
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批准号:19590696
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.33万
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财政年份:2007
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依托单位:
A Study on the formation of Environmental education Bases by Ccoperation among schools in Asia, Africa, and Japan
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批准号:18500666
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.59万
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财政年份:2006
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负责人:KITA Masakazu
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依托单位:
Development of complementary and alternative medicine against antibiotic-resistant Helicobacter pylori infection
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批准号:15590602
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2003
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负责人:KITA Masakazu
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依托单位:
Animal model of stomach carcinogenesis in mice infected with Helicobacter pylori
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批准号:10680779
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.7万
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财政年份:1998
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负责人:KITA Masakazu
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依托单位:
The Study of The Second-Order Asymmetric Transformation in Metal Complexes
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批准号:09640669
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:1997
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负责人:KITA Masakazu
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依托单位:
Synthesis and Reaction of Metal Complexes Containing Sulfur, Selenium, and Tellurium donor atoms.
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批准号:06640727
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资助金额:$1.41万
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财政年份:1994
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负责人:KITA Masakazu
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依托单位:
海外基金