Alternative therapies for antibiotic-resistant Helicobacter pylori infection

幽门螺杆菌(Hp)感染与胃炎、消化性溃疡、胃癌等胃肠道疾病的发生密切相关。由PPI和两种抗生素组成的标准三联疗法被广泛用于感染的治疗，但幽门螺杆菌对克拉霉素和甲硝唑的耐药性增加已显著降低了根治率。本研究对18种中草药的体内外抑菌作用进行了研究。几种中草药在体外对耐药菌株Hp的生长有抑制作用，剂量为1 mg/ml。3种中药(黄连、甘草、丁香花)均能显著降低小鼠胃内幽门螺杆菌的感染密度。这些结果表明，草药可能有潜力作为治疗耐药幽门螺杆菌感染的补充和替代药物。

Helicobacter pylori (H. pylori) infection is highly associated with the occurrence of gastrointestinal diseases, including gastric inflammation, peptic ulcer and gastric cancer. The standard triple therapy consisting of PPI and two antibiotics is widely used as the regimen for treatment of infection, but the increased resistance of H. pylori to clarithromycin and metronidazole has significantly reduced the eradication rate. In this study, the antimicrobial effect of 18 herbal medicines was evaluated in vitro and in vivo. Several herbal medicines inhibited the growth of antibiotic-resistant strains of H. pylori at a dose of 1 mg/ml in vitro. On the other hand, the density of H. pylori in the stomach of mice treated with 3 herbal medicines (Coptidis Rhizoma, Glycyrrhizae Radix and Caryophylli Flos) was significantly reduced. These results suggest that herbal medicines may have potential as complementary and alternative medicines for treatment of antibiotic-resistant H. pylori infection.