Alternative therapies for antibiotic-resistant Helicobacter pylori infection

幽门螺杆菌（Helicobacter pylori， H. pylori）感染与胃炎症、消化性溃疡、胃癌等胃肠道疾病的发生高度相关。目前广泛采用由PPI和两种抗生素组成的标准三联疗法作为治疗感染的方案，但幽门螺杆菌对克拉霉素和甲硝唑的耐药性增加，大大降低了根除率。本研究对18种中草药的体外和体内抑菌效果进行了评价。几种草药在体外以1mg /ml的剂量抑制幽门螺杆菌耐药菌株的生长。另一方面，3种中药（黄连、甘草、石竹）均可显著降低小鼠胃内幽门螺杆菌的密度。这些结果表明，草药可能有潜力作为治疗耐药幽门螺杆菌感染的补充和替代药物。

Helicobacter pylori (H. pylori) infection is highly associated with the occurrence of gastrointestinal diseases, including gastric inflammation, peptic ulcer and gastric cancer. The standard triple therapy consisting of PPI and two antibiotics is widely used as the regimen for treatment of infection, but the increased resistance of H. pylori to clarithromycin and metronidazole has significantly reduced the eradication rate. In this study, the antimicrobial effect of 18 herbal medicines was evaluated in vitro and in vivo. Several herbal medicines inhibited the growth of antibiotic-resistant strains of H. pylori at a dose of 1 mg/ml in vitro. On the other hand, the density of H. pylori in the stomach of mice treated with 3 herbal medicines (Coptidis Rhizoma, Glycyrrhizae Radix and Caryophylli Flos) was significantly reduced. These results suggest that herbal medicines may have potential as complementary and alternative medicines for treatment of antibiotic-resistant H. pylori infection.