Immunoregulation by the unique lymphocytes in liver

肝脏中独特的淋巴细胞的免疫调节作用

• 批准号: 19590754
• 负责人: ABO Toru
• 金额: $ 2.91万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590754/
• 关键词: 肝臓; リンパ球; NKT細胞; γδT細胞; 自己免疫疾患; B細胞; 自己抗体; 自然免疫; 胸腺外分化T細胞; NK細胞

マラリア感染において、肝臓に多く存在し、原虫の排除に重要であるNKT細胞やCD8+T細胞を欠如するマウスにマラリア原虫を感染させたところ、NK細胞やγδT細胞がマラリア排除に重要であることが分かった。その中でも特にγδT細胞が不可欠なエフェクターであることを明らかにした。また、新生児期、加齢期や自己免疫性肝炎発症後しばらくして、独特な自己抗体を産生するB細胞が増殖してくることを明らかにし、それらの細胞の特性について検討した。

The parasites were infected, the liver was infected, the protozoa excluded the important NKT cells, the CD8+T cells were not as important as the protozoa, the protozoa were infected with the protozoa, the NK cells were infected with γ T cells, the parasites were excluded from the important cells. In the middle of the day, there is a special γ δ T cell that can't be owed to you. In the first, newborn and late stages of autoimmune hepatitis, the disease is characterized by the production of specific antibodies, the production of B cells, the production of specific antibodies, the production of B cells, the production of specific antibodies, the production of specific antibodies, the production of B cells, the production of specific antibodies, the production of B cells, the proliferation of cells, and the characteristics of cells.

项目成果

Appearance of B220low autoantibody‐producing B‐1 cells at neonatal and older stages in mice

小鼠新生期和老年期产生 B220low 自身抗体的 B-1 细胞的出现

• DOI: 10.1111/j.1365-2249.2008.03709.x
• 发表时间: 2008
• 期刊: Clinical & Experimental Immunology
• 影响因子: 4.6
• 作者: S. Tachikawa;T. Kawamura;H. Kawamura;Yasuhiro Kanda;Y. Fujii;Hiroaki Matsumoto;Toru Abo
• 通讯作者: Toru Abo

Malaria protection in β-microglobulin-deficient mice lacking major histocompatibility complex class Iantigens: essential role of innate immunity, including yδ cells.

缺乏主要组织相容性复合物类抗原的 β-微球蛋白缺陷型小鼠的疟疾保护：先天免疫（包括 yδ 细胞）的重要作用。

• 发表时间: 2007
• 期刊: Immunology 122
• 作者: 谷口委代;太刀川彩保子;神田泰洋;他2名
• 通讯作者: 他2名

正常マウスでのNKT細胞活性化による自己抗体産生

正常小鼠中 NKT 细胞激活产生自身抗体

• 发表时间: 2008
• 作者: 陳正新;坂本直哉;井津井康浩;中川美奈;櫻井幸;須田剛生;山本満千;小貫優子;三島果子;渡辺守;松本浩晃
• 通讯作者: 松本浩晃

Malaria protection in β2‐microglobulin‐deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including γδT cells

• DOI: 10.1111/j.1365-2567.2007.02661.x
• 发表时间: 2007-12
• 期刊: Immunology
• 影响因子: 6.4
• 作者: T. Taniguchi;S. Tachikawa;Yasuhiro Kanda;T. Kawamura;C. Tomiyama-Miyaji;Changchun Li;Hisami Watanabe;H. Sekikawa;T. Abo

Relationship between diseases accompanied by tissue destruction and granulocytes with surface adrenergic receptors

• DOI: 10.1007/bf02697370
• 发表时间: 2007-01-01
• 期刊: IMMUNOLOGIC RESEARCH
• 影响因子: 4.4
• 作者: Abo, Toru;Kawamura, Toshihiko;Kanda, Yasuhiro
• 通讯作者: Kanda, Yasuhiro