Effect of incretin on beta cell proliferation and prevention of diabetes
Effect of incretin on beta cell proliferation and prevention of diabetes
批准号:
19591046
负责人:
SEINO Yutaka
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
点击翻译按钮获取中文摘要
英文摘要
膵β細胞機能の障害は糖尿病発症の重要な要因である。腸管から分泌されインスリン分泌促進作用を持つホルモンであるインクレチンの一つ、GLP-1のアナログの投与により、糖尿病モデルマウスの膵β細胞障害を抑制し、膵β細胞の数・量が保たれ、血糖の上昇が抑制されることが示された。今後β細胞障害抑制機序の詳細に関して、さらなる組織学的・分子学的検討を継続し、そのメカニズムを解明する。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
GLP-1シグナルの増強はAkitaマウスの膵β細胞障害を抑制する
GLP-1 信号增强可抑制秋田小鼠胰腺 β 细胞损伤
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[山根俊介, 原田範雄, 山田千積, 豊田健太郎, 浜本芳之, 清野裕, 稲垣暢也]
通讯作者:
稲垣暢也
GLP-1 receptor activation attenuates beta cell damage in Akita mice
GLP-1 受体激活可减轻秋田小鼠的 β 细胞损伤
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[山根俊介, 浜本芳之, 原田範雄, 豊田健太郎, 清野裕, 稲垣暢也]
通讯作者:
稲垣暢也
Investigation for intracellular mechanisms of pancreatic-cell proliferation and anti-apoptotic effect of incretin
-
批准号:21591132
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2009
-
负责人:SEINO Yutaka
-
依托单位:
Analysis of transcriptional network in pancreatic β-cells
-
批准号:12470228
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.15万
-
财政年份:2000
-
负责人:SEINO Yutaka
-
依托单位:
Characterizetion of glucose-induced signal transduction and its impairment in type 2 diabete
-
批准号:09470219
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.45万
-
财政年份:1997
-
负责人:SEINO Yutaka
-
依托单位:
Development of new hypoglycemic agents with a novel insulinotropic mechanism and their clinical appkicatior
-
批准号:08557060
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$6.02万
-
财政年份:1996
-
负责人:SEINO Yutaka
-
依托单位:
A study on the beta-Cell glucose sensors in insulin secretion : The relationship between dysfunction of glucose sensors and development of diabetes mellitus
-
批准号:07044256
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$7.36万
-
财政年份:1995
-
负责人:SEINO Yutaka
-
依托单位:
Development of new hypoglycemic agents with a novel insulinotropic mechanism and their clinical application
-
批准号:06557057
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$7.1万
-
财政年份:1994
-
负责人:SEINO Yutaka
-
依托单位:
The analysis of transcriptional regulation in a series of glucose responsive genes.
-
批准号:05454321
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.35万
-
财政年份:1993
-
负责人:SEINO Yutaka
-
依托单位:
Roles of various types of glucose transporter gene in diabetes mellitus
-
批准号:03044088
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$6.72万
-
财政年份:1991
-
负责人:SEINO Yutaka
-
依托单位:
Studies on molecular mechanism of etiology of diabetes mellitus
-
批准号:02671093
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1990
-
负责人:SEINO Yutaka
-
依托单位:
The role of somatostatin in pathophysiology of obesity and diabetes mellitus
-
批准号:60570529
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.09万
-
财政年份:1985
-
负责人:SEINO Yutaka
-
依托单位:
海外基金