Analysis of the expression of the brain-specific aromatase gene for the sexual dimorphic nucleus in the brain

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The aromatase has a critical role in sexual differentiation of the brain. To clarify neuronal-specific, sexual-specific, and spatiotemporal expression mechanisms of aromatase gene, I analyzed brain-specific promoter region of the gene. I identified several transcription factors that act on the cis-elements in the brain-specific promoter region. Furthermore, I also determined the aromatase-expressing neurons in central nervous system using transgenic mice. In this study, I have found that important information of resolution for the construction on the sexual differentiation of the brain in mammal.