Pathogen eradication mediated by receptor for IgM natural antibody

IgM 天然抗体受体介导的病原体根除

• 批准号: 24659175
• 负责人: HONDA Shinichiro
• 金额: $ 2.5万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659175/
• 关键词: Fc受容体; 自然抗体; 敗血症; IgA; IgM

Natural IgM antibody recognizes various pathogen components and contributes to eradication of pathogens. We found that mice lacking IgM Fc receptor, Fca/mR (CD351), showed reduced inflammatory cytokines production against lipopolysaccharide (LPS) and improved survival against septic shock. We also found that marginal zone B cells (MZBs), highly expressing Fca/mR, largely contribute inflammatory cytokines production against LPS. Thus, Fca/mR regulates inflammatory cytokine production from MZB, leading to the regulation of systemic inflammatory responses during LPS-induced septic shock.

天然的IgM抗体识别各种病原体成分，有助于根除病原体。我们发现，缺乏IgM Fc受体FCA/MR(CD351)的小鼠表现出对内毒素(LPS)的炎性细胞因子产生减少，并提高了抗感染性休克的存活率。我们还发现，高表达FCA/MR的边缘区B细胞(MZB)在很大程度上促进了针对内毒素的炎性细胞因子的产生。因此，FCA/MR调节MZB产生的炎性细胞因子，从而调节内毒素诱导的感染性休克期间的全身炎症反应。

项目成果

Involvement of CD300a in the pathogenesis of DSS-induced colitis.

CD300a 参与 DSS 诱导的结肠炎的发病机制。

• 作者: Nakazawa Y;Iino S;Nakahashi-Oda C;Shibuya A.
• 通讯作者: Shibuya A.

Involvement of Fcα/μR (CD351) in autoantibody production

Fcα/μR (CD351) 参与自身抗体的产生

• DOI: 10.1016/j.molimm.2013.10.002
• 发表时间: 2013
• 期刊: Mol Immunol
• 影响因子: 3.6
• 作者: Yoshizawa Y;Honda S;Shibuya A
• 通讯作者: Shibuya A

Fca/mR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock.

Fca/mR (CD351) 调节边缘区 B 细胞针对实验性感染性休克的炎症反应。

• 作者: Honda S;Yoshizawa Y;Sato K;Fujimoto M;Nakahashi-Oda C;Tahara-Hanaoka S;Shibuya K;Shibuya A.
• 通讯作者: Shibuya A.

Follicular dendritc cells (FDC) internalized IgM-coated antigen via Fc receptor for IgA/IgM (Fcα/μR; CD351)

滤泡树突细胞 (FDC) 通过 IgA/IgM 的 Fc 受体内化 IgM 包被的抗原 (Fcα/μR; CD351)

• 发表时间: 2012
• 作者: Sato K;Usui K;Honda S;Yoshizawa Y;Shibuya A.
• 通讯作者: Shibuya A.

Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.

• DOI: 10.1084/jem.20120096
• 发表时间: 2012-07-30
• 期刊: The Journal of experimental medicine
• 作者: Nakahashi-Oda C;Tahara-Hanaoka S;Shoji M;Okoshi Y;Nakano-Yokomizo T;Ohkohchi N;Yasui T;Kikutani H;Honda S;Shibuya K;Nagata S;Shibuya A
• 通讯作者: Shibuya A