Regulatory mechanism of FDC activation via Fca/mR

Fca/mR激活FDC的调控机制

• 批准号: 23390091
• 负责人: HONDA Shinichiro
• 金额: $ 12.65万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390091/
• 关键词: 濾胞樹状細胞; IgM; Fc受容体; Fc 受容体; IgA

Follicular dendritic cells (FDCs) capture and retain antigen for long period to activate cognate B cells, leading to germinal center formation. We established a novel method for FDCs isolation from lymphoid organs of naive mice. Surprisingly, analysis with this method showed that FDCs internalized capturing antigen via Fca/mR. Aa a result of this internalization, antigen amount on FDCs cells surface was decreased. These results suggested that Fca/mR regulates antigen amount on FDCs cell surface, leading to the regulation of B cells activation and germinal center formation.

滤泡树突状细胞（Follicular dendritic cells，FDCs）捕获并长期保留抗原，激活同源B细胞，形成生发中心。我们建立了一种从幼稚小鼠淋巴器官中分离FDCs的新方法。令人惊讶的是，用该方法进行的分析显示，FDC通过Fca/mR内化捕获抗原。由于这种内化，FDC细胞表面上的抗原量减少。提示Fca/mR通过调节FDCs细胞表面抗原的数量，调节B细胞的活化和生发中心的形成。

项目成果

Molecular characterization of the dimer formation of Fcα/μ receptor (CD351)

Fcα/μ 受体 (CD351) 二聚体形成的分子表征

• DOI: 10.1016/j.molimm.2013.04.003
• 发表时间: 2013
• 期刊: Mol Immunol
• 影响因子: 3.6
• 作者: Takagaki K;Satoh K;Honda S;Shibuya A
• 通讯作者: Shibuya A

Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor

• DOI: 10.1016/j.bbrc.2011.12.025
• 发表时间: 2012-01-06
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Nakahashi-Oda, Chigusa;Tahara-Hanaoka, Satoko;Shibuya, Akira
• 通讯作者: Shibuya, Akira

The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.

免疫受体衔接蛋白DAP12抑制了B淋巴细胞驱动的适应性免疫反应。

• DOI: 10.1084/jem.20101623
• 发表时间: 2011-08-01
• 期刊: The Journal of experimental medicine
• 作者: Nakano-Yokomizo T;Tahara-Hanaoka S;Nakahashi-Oda C;Nabekura T;Tchao NK;Kadosaki M;Totsuka N;Kurita N;Nakamagoe K;Tamaoka A;Takai T;Yasui T;Kikutani H;Honda S;Shibuya K;Lanier LL;Shibuya A
• 通讯作者: Shibuya A

Involvement of Fcα/μR (CD351) in autoantibody production

Fcα/μR (CD351) 参与自身抗体的产生

• DOI: 10.1016/j.molimm.2013.10.002
• 发表时间: 2013
• 期刊: Mol Immunol
• 影响因子: 3.6
• 作者: Yoshizawa Y;Honda S;Shibuya A
• 通讯作者: Shibuya A

Isolation and characterization of naive follicular dendritic cells

幼稚滤泡树突状细胞的分离和表征

• DOI: 10.1016/j.molimm.2011.11.010
• 发表时间: 2012
• 期刊: Molecular Immunology
• 影响因子: 3.6
• 作者: DOHI;Toshifumi;仲野徹;Kenta Usui
• 通讯作者: Kenta Usui