Relationship between heterogenity of gene expression and differentiation
Relationship between heterogenity of gene expression and differentiation
批准号:
19591120
负责人:
SAKAMOTO Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
c-mybは血液細胞の増殖だけでなく分化にも影響する転写因子である。そこで、本研究では、その発現をモニターし分化への影響を詳細に検討する為に遺伝子改変マウスの樹立を試みた。最初の方法論ではc-mybモニターES細胞は完成しなかった。しかし、技術的改良により、目的のES細胞は樹立でき、現在このES細胞を用いた遺伝子改変マウスの作成を始めている。この結果は、世界初のc-mybモニターマウス誕生へと繋がり、このマウスを用いての血液細胞分化研究へ貢献出来ると考える。
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Thrombopoietin receptor, c-mpl, is a marker of early hematopoietic progenitors in mouse embryo.
血小板生成素受体 c-mpl 是小鼠胚胎中早期造血祖细胞的标志物。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[黄〓, 坂本比呂志, 小川峰太郎, 黄 〓]
通讯作者:
黄 〓
トロンボポエチンによるJAK2-STAT5を介した胎児型の多分化血液細胞の増殖
JAK2-STAT5介导的血小板生成素促进胎儿型多分化血细胞增殖
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[坂本比呂志, 黄〓, 小川峰太郎]
通讯作者:
小川峰太郎
Thrombopoietin controls proliferation of embryonic multipotent hematopoietic progenitors
血小板生成素控制胚胎多能造血祖细胞的增殖
DOI:
--
发表时间:
期刊:
Genes to Cells (in press)
影响因子:
--
作者:
[Huang X, Sakamoto H, and Ogawa M]
通讯作者:
and Ogawa M
Notchシグナルの下流因子によるES細胞由来内皮細胞の反応
Notch 信号下游因子对 ES 细胞来源的内皮细胞的反应
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[坂本比呂志, 松川舞, 郭仁勇, 小川峰太郎]
通讯作者:
小川峰太郎
造血発生の発生分化におけるc-Myb発現レベルの意義血液・腫瘍科
c-Myb 表达水平在造血发育分化中的意义 血液学/肿瘤学
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[坂本比呂志, 小川峰太郎]
通讯作者:
小川峰太郎
共 12 条
Investigation of catalytic mechanism of heme oxygenase and protein-protein interaction among its related enzymes
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批准号:24510301
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
-
财政年份:2012
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负责人:SAKAMOTO Hiroshi
-
依托单位:
Analysis of the mechanisms of HSC maintenance and differentiation utilizing c-Myb reporter mice
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批准号:24591400
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
-
财政年份:2012
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负责人:SAKAMOTO Hiroshi
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依托单位:
Comprehensive identification of abnormally spliced RNAs and elucidation of their significance
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批准号:23510234
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2011
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负责人:SAKAMOTO Hiroshi
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依托单位:
Can data compression algorithm do abstraction?
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批准号:23650074
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:SAKAMOTO Hiroshi
-
依托单位:
Compressed Mining: exposing hidden knowledge in large-scale data
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批准号:23680016
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$12.56万
-
财政年份:2011
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负责人:SAKAMOTO Hiroshi
-
依托单位:
A Study of the Thought and Style of Journalism of Postwar Japan
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批准号:22730400
-
项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$0.92万
-
财政年份:2010
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负责人:SAKAMOTO Hiroshi
-
依托单位:
Regional Disparity in China using Non-parametric Approach
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批准号:21530247
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.58万
-
财政年份:2009
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Molecular analysis of effects of HUB molecules in transcription factor network on cell differentiation
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批准号:21591208
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2009
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负责人:SAKAMOTO Hiroshi
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依托单位:
Rapid pattern discovery from huge semi-structured data based on local structure in graph
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批准号:20700143
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.33万
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财政年份:2009
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Development of New Generation Readout System for the ATLAS Muon System Based on High Performance Advanced Logic Devices
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批准号:21540296
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
-
财政年份:2009
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
A Study of Historical Sociology on Modern Publication : Focused on Soihi Oya
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批准号:20730343
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.0万
-
财政年份:2008
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Regional Disparity and Convergence in China : Using Markov Chain
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批准号:18730182
-
项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.25万
-
财政年份:2006
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Enzyme chemical study of heme oxygenase and development for machinery of heme catabolism
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批准号:18550153
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.59万
-
财政年份:2006
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Analysis of the mrg-1 gene function required for differentiation of primordial germ cells in the nematode C.elegans
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批准号:16606003
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2004
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Discovery of Higgs Particles by using the ATLAS Detector at LHC
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批准号:16081204
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$171.84万
-
财政年份:2004
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
How does heme degrade ? -Studies of the catalytic mechanism of heme oxygenase based on its crystal structures-
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批准号:15550155
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2003
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Regulative mechanisms of cell proliferation and differentiation by RNA-binding proteins
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批准号:14035235
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$75.14万
-
财政年份:2002
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负责人:SAKAMOTO Hiroshi
-
依托单位:
Functional analysis of Hu proteins that induce neuronal differentiation
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批准号:12480210
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2000
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负责人:SAKAMOTO Hiroshi
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依托单位:
Development of New Type Snowbreak Fence with Induced Plate in the Form of Circular Arc Airfoil for Prevention of Blowing-Snow Disasters
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批准号:12558042
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.85万
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财政年份:2000
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负责人:SAKAMOTO Hiroshi
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依托单位:
Development of Object-Oriented, Network-Distributed Online Environment
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批准号:10640263
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:1998
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负责人:SAKAMOTO Hiroshi
-
依托单位:
海外基金