Enzyme chemical study of heme oxygenase and development for machinery of heme catabolism
Enzyme chemical study of heme oxygenase and development for machinery of heme catabolism
批准号:
18550153
负责人:
SAKAMOTO Hiroshi
金额:
$2.59万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2008
中文摘要
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英文摘要
ヘムオキシゲナーゼ(HO)はヘム代謝系の律速酵素で、NADPH-シトクロムP450還元酵素から電子の供給を受け、ヘムを3段階からなる酸素依存性の反応によって分解し、ビリベルジン、一酸化炭素および鉄イオンを生成する。ビリベルジンは、ビリベルジン還元酵素によって直ちにビリルビンに還元される。本研究では、HOの触媒作用機序の解明と、ヘム代謝酵素および関連タンパク質の相互作用の探求を総合的に展開し、HOの生理機能を分子レベルで理解するための基盤作りを行った。
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CO配位型ベルドヘム-ヘムオキシゲナーゼ複合体のオキサポルフィリン環の還元
CO配位的绿血红素-血红素加氧酶复合物的氧杂卟啉环的还原
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[佐藤秀明, 東元祐一郎, 坂本寛, 杉島正一, 下川千寿, 原田沙織, 野口正人]
通讯作者:
野口正人
Functional Analysis of Heme Regulatory Motifs of Rat Heme Oxygenase-2
大鼠血红素氧化酶2血红素调节基序的功能分析
DOI:
--
发表时间:
2009
期刊:
In : Nomizu, M. (Ed.): Peptide Sci-ence 2008. Protein Research Foundation, Osaka
影响因子:
--
作者:
[Nakashima, S., Higashimoto, Y., Noguchi, Y., and Sakamoto, H.]
通讯作者:
H.
ラットHeme oxygenase-1のヘム結合の熱力学的特性に与えるイオン強度変化の影響
离子强度变化对大鼠血红素加氧酶-1 血红素结合热力学性质的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[岩崎浩之, 大村昇, 野口正人, 東元祐一郎, 小松英幸, 坂本寛]
通讯作者:
坂本寛
蛍光ラベル化Heme oxygenase-1を利用したヘムセンサーの開発
使用荧光标记的血红素加氧酶-1开发血红素传感器
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[A. Sumino, et. al., 鈴居詠之郎]
通讯作者:
鈴居詠之郎
ラットヘムオキシゲナーゼ-1によるヘム結合のカロリメトリー解析
大鼠血红素加氧酶 1 血红素结合的量热分析
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[大村昇, 田中知子, 小松秀幸, 東元祐一郎, 野口正人, 坂本寛]
通讯作者:
坂本寛
共 67 条
Investigation of catalytic mechanism of heme oxygenase and protein-protein interaction among its related enzymes
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批准号:24510301
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
-
财政年份:2012
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负责人:SAKAMOTO Hiroshi
-
依托单位:
Analysis of the mechanisms of HSC maintenance and differentiation utilizing c-Myb reporter mice
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批准号:24591400
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:SAKAMOTO Hiroshi
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依托单位:
Comprehensive identification of abnormally spliced RNAs and elucidation of their significance
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批准号:23510234
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2011
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负责人:SAKAMOTO Hiroshi
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依托单位:
Can data compression algorithm do abstraction?
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批准号:23650074
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2011
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Compressed Mining: exposing hidden knowledge in large-scale data
-
批准号:23680016
-
项目类别:Grant-in-Aid for Young Scientists (A)
-
资助金额:$12.56万
-
财政年份:2011
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
A Study of the Thought and Style of Journalism of Postwar Japan
-
批准号:22730400
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$0.92万
-
财政年份:2010
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Regional Disparity in China using Non-parametric Approach
-
批准号:21530247
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.58万
-
财政年份:2009
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Molecular analysis of effects of HUB molecules in transcription factor network on cell differentiation
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批准号:21591208
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2009
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Rapid pattern discovery from huge semi-structured data based on local structure in graph
-
批准号:20700143
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.33万
-
财政年份:2009
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Development of New Generation Readout System for the ATLAS Muon System Based on High Performance Advanced Logic Devices
-
批准号:21540296
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2009
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
A Study of Historical Sociology on Modern Publication : Focused on Soihi Oya
-
批准号:20730343
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.0万
-
财政年份:2008
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Relationship between heterogenity of gene expression and differentiation
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批准号:19591120
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Regional Disparity and Convergence in China : Using Markov Chain
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批准号:18730182
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.25万
-
财政年份:2006
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Analysis of the mrg-1 gene function required for differentiation of primordial germ cells in the nematode C.elegans
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批准号:16606003
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2004
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Discovery of Higgs Particles by using the ATLAS Detector at LHC
-
批准号:16081204
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$171.84万
-
财政年份:2004
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
How does heme degrade ? -Studies of the catalytic mechanism of heme oxygenase based on its crystal structures-
-
批准号:15550155
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2003
-
负责人:SAKAMOTO Hiroshi
-
依托单位:
Regulative mechanisms of cell proliferation and differentiation by RNA-binding proteins
-
批准号:14035235
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$75.14万
-
财政年份:2002
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负责人:SAKAMOTO Hiroshi
-
依托单位:
Functional analysis of Hu proteins that induce neuronal differentiation
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批准号:12480210
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
-
财政年份:2000
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负责人:SAKAMOTO Hiroshi
-
依托单位:
Development of New Type Snowbreak Fence with Induced Plate in the Form of Circular Arc Airfoil for Prevention of Blowing-Snow Disasters
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批准号:12558042
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.85万
-
财政年份:2000
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负责人:SAKAMOTO Hiroshi
-
依托单位:
Development of Object-Oriented, Network-Distributed Online Environment
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批准号:10640263
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
-
财政年份:1998
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负责人:SAKAMOTO Hiroshi
-
依托单位:
海外基金