Regulative mechanisms of cell proliferation and differentiation by RNA-binding proteins

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We have shown the following findings :1. Neuronal RNA-binding protein HuD acts as adaptor molecule for the general mRNA transport receptor TAP/NXF1. HuD also functions as a translational activator through interaction with both translation initiation factors and polyA-binding protein PABP.2. EXC-7, a C. elegans homologue of HuD, is involved in the formation of the excretory canal.3. An RNA-binding protein Y14, a component of exon-exon junction complex, is involved in the sexual differentiation of germ cells in C. elegans.4. An RNA-binding protein RBD-1 is required for processing of 18S ribosomal RNA in C. elegans.5. MRG-1, a C. elegans chromodomain protein, is a maternal factor which is required for germ cell formation and is involved in repression of sex chromosome gene expression.6. Mmi1p, a S. pombe RNA-binding protein, functions to remove meiosis-specific mRNAs in mitotic stage cells.