Analysis of the new mechanism on degradation of Synphilin associated with the formation of Lewy body
Analysis of the new mechanism on degradation of Synphilin associated with the formation of Lewy body
批准号:
19790609
负责人:
NAKAMURA Takeshi
金额:
$2.44万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
神経変成疾患であるパーキンソン病は振戦、動作緩慢などを主症状とする。発症原因はいまだ不明であるが脳内の黒質ドパミン神経の減少が認められる。黒質ドパミン神経細胞に出現するLewy小体を構成するsynphilinはパーキンソン病発症の分子機構に関与する重要なタンパク質と考えられている。Synphilinトランスジェニックマウスを作成し病理学的には異常は認めなかったがドパミンならびにその代謝産物の低下を認めた。
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DOI:
10.1016/j.neulet.2008.08.073
发表时间:
2008-11-07
期刊:
NEUROSCIENCE LETTERS
影响因子:
2.5
作者:
[Jin, Hong-Guo, Yamashita, Hiroshi, Matsumoto, Masayasu]
通讯作者:
Matsumoto, Masayasu
Synphilin-1トランスジェニックマウスの中枢神経系の組織学的解析
Synphilin-1转基因小鼠中枢神经系统的组织学分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Jin HG, Yamashita H, Nakamura T, Fukuba H, Takahashi T, Hiji M, Kohriyama T, Matsumoto M, 山下拓史, 金洪国, 金洪国]
通讯作者:
金洪国
Synphilin-1トランスジェニックマウスの中枢神経系の組織学的検討
Synphilin-1转基因小鼠中枢神经系统的组织学检查
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Jin HG, Yamashita H, Nakamura T, Fukuba H, Takahashi T, Hiji M, Kohriyama T, Matsumoto M, 山下拓史, 金洪国]
通讯作者:
金洪国
Synphilin-1トランスジェニックマウスの表現型の解析
Synphilin-1转基因小鼠的表型分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Jin HG, Yamashita H, Nakamura T, Fukuba H, Takahashi T, Hiji M, Kohriyama T, Matsumoto M, 山下拓史]
通讯作者:
山下拓史
Analysis of molecular network regulating spatiotemporal activities of three G proteins that control membrane traffic during outgrowth of growth cones
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批准号:15K06782
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2015
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负责人:NAKAMURA Takeshi
-
依托单位:
The development of beneficial exercise under noninvasive positive pressure ventilation for physical activity and health
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批准号:15K01382
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2015
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负责人:NAKAMURA Takeshi
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依托单位:
Analysis of the regulation-mechanism of intracellular dynamics of late endosome and lysosome by using a FRET biosensor
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批准号:24657094
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
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财政年份:2012
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负责人:NAKAMURA Takeshi
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依托单位:
The cultural history of election and citizenship in modern Britain : the case of metropolitan London, 1780-1837
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批准号:21720271
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2009
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负责人:NAKAMURA Takeshi
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依托单位:
Seismic waveform simulation in oceanic area
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批准号:21740334
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.33万
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财政年份:2009
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负责人:NAKAMURA Takeshi
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依托单位:
Combined analysis of feedback loops consisting of G proteins and phospholipid in the formation of neural cirnuitry
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批准号:18500295
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
-
财政年份:2006
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负责人:NAKAMURA Takeshi
-
依托单位:
Multidimensional analysis of small GTPases as key molecules in the neural network formation by using activity-imaging
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批准号:16500242
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:2004
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负责人:NAKAMURA Takeshi
-
依托单位:
Beam Intensity Upgrade of a Storage Ring by Curing Instabilities by Chromaticity Modulation and its Usage Test
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批准号:16360043
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.45万
-
财政年份:2004
-
负责人:NAKAMURA Takeshi
-
依托单位:
New evaluation method of seismic resistant capacity and reexamination of earthquake resistant design standard for wooden structures
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批准号:11555151
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$1.22万
-
财政年份:1999
-
负责人:NAKAMURA Takeshi
-
依托单位:
Studies on hemolysin of Anginosus group streptococci isolated from the human oral cavity
-
批准号:11671826
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1999
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负责人:NAKAMURA Takeshi
-
依托单位:
Dark Matter and Macho of the Galaxy
-
批准号:07640399
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1995
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负责人:NAKAMURA Takeshi
-
依托单位:
Investigation of proteases responsible for degradation of periodontal tissue by periodontopathogens
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批准号:05671528
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.15万
-
财政年份:1993
-
负责人:NAKAMURA Takeshi
-
依托单位:
Biochemical Studies on Contractile and Regulatory System of Muscle from Cestode.
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批准号:01570220
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1989
-
负责人:NAKAMURA Takeshi
-
依托单位:
Studies on ecological activity and enzymes of periodontopathogens
-
批准号:63570883
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1988
-
负责人:NAKAMURA Takeshi
-
依托单位:
海外基金