Expression, inactivation and mutation analysis of the candidate genes for Autism

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To clarify the pathogenesis of autistic spectrum disorder (ASD),we analyzed the expression level and mutation of DLX5、DLX6、BDNF、SGK1、FXYD1、IGF2 and IGFBP3.In DLX6, we detected a base change in 2 ASD patients. The expression level of DLX5 was not different between ASD and controls but was higher in four ASD patients compared to controls. In SGK1, the expression level of the ASD group was higher than the control group significantly.DLX5, DLX6 and SGK1 is considered to relate with autism.