Development of anti-hard keratin antibody and expression mechanism analysis of shadow cell

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In this study, the involvement of Wnt signaling transduction pathway in the presence of ghost cells and shadow cells in the calcifying cystic odontogenic tumor, odontoma, pilomatrixoma and adamantinomatous craniopharingioma was examined by an immunohistochemical method. Ghost cells and shadow cells showed strong reactivity for antibodies against hair protein. In the epithelial components around these cells, the increased expression of β-catenin was found in the nucleus and cytoplasm, and the positive reaction for Lef-1 was seen in the nucleus. These findings suggest that the presence of ghost cell and shadow cell in the hard keratin expressing tumors are involved in Wnt signaling transduction pathway.