Analysis of alterations by stably expressing or suppressing SCCA gene in an oral squamous cell carcinoma cell line

口腔鳞状细胞癌细胞系中 SCCA 基因稳定表达或抑制引起的变化分析

• 批准号: 19791558
• 负责人: HASHIMOTO Kenichiro
• 金额: $ 2.21万
• 依托单位: Fukuoka Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791558/
• 关键词: 臨床腫瘍学; SCCA; 口腔扁平上皮癌; 個別化治療法

This study examined the tumorigenic effect of SCCA (Squamous cell carcinoma antigen) by stably expression or suppuression in an oral squamous cell carcinoma cell line. There was no significant difference in the cellular morphology or proliferative activity, which could have been caused by SCCA transfection, between the SCCA suppressive transfectants and the controls. These results suggested that SCCA do not directly play a role in the cellular morphology or proliferative activity.

本研究考察了SCCA（鳞状细胞癌抗原）在口腔鳞状细胞癌细胞系中稳定表达或抑制的致瘤作用。在SCCA抑制剂和对照组之间，细胞形态和增殖活性没有显著差异，这可能是由SCCA转染引起的。这些结果表明，SCCA不直接影响细胞形态或增殖活性。