Analysis of alterations by stably expressing or suppressing SCCA gene in an oral squamous cell carcinoma cell line

本研究探讨了鳞状细胞癌抗原（SCCA）在口腔鳞状细胞癌细胞系中稳定表达或抑制表达的致瘤作用。在SCCA抑制性转染子和对照之间，细胞形态或增殖活性没有显著差异，这可能是由SCCA转染引起的。这些结果表明，SCCA不直接发挥作用的细胞形态或增殖活性。

This study examined the tumorigenic effect of SCCA (Squamous cell carcinoma antigen) by stably expression or suppuression in an oral squamous cell carcinoma cell line. There was no significant difference in the cellular morphology or proliferative activity, which could have been caused by SCCA transfection, between the SCCA suppressive transfectants and the controls. These results suggested that SCCA do not directly play a role in the cellular morphology or proliferative activity.