Effect of maternal deprivation in the early period on immobilization stress reaction in the adult rat, -the evaluation of a central nervous system mechanism-

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The immobilization stress-induced corticosterone levels were significantly lower in the MD(6-OHDA) group than in MD(saline) group and control group at T30. Plasma CORT levels were significantly higher in the MD(saline) group than other groups at T180, on the other hand, plasma CORT levels in control group returned to the basal level at T180. In MD(6-OHDA) group, although the peak of plasma CORT levels were low, plasma CORT levels decreased more slowly following termination of stress, and did not return to the basal level at T180. These results suggested that the maternal deprivation in early period produce a long-term effect on the hippocampus of MD rat that was involved in the negative feedback regulation of glucocorticoids.