Elucidation of immune escape mechanisms by periodontopathic bacteria

阐明牙周病细菌的免疫逃逸机制

• 批准号: 19791610
• 负责人: HONDA Tomoyuki
• 金额: $ 2.38万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791610/
• 关键词: 歯周病原細菌; Porphyromonas gingivalis; IRAK-M; マクロファージ; Lipopolysaccharide; Toll-like receptor

歯周病原因細菌の1つPorphyromonas gingivalis は,免疫による排除機構から逃れ,感染を慢性化させている可能性が考えられる.この細菌のもつ病原因子が歯周組織の構成細胞(マクロファージ,上皮細胞)によって認識される過程においてIRAK-M の発現が高まる.IRAK-M は免疫を抑制する分子の一つとして既に知られているが,歯周組織の細胞においても免疫応答性を低下させ,感染を慢性化させるメカニズムの一端が明らかとなった.

The cause of the disease was 1 Porphyromonas gingivalis, the immune elimination mechanism fled, and the possibility of infection with chronic disease was tested. Bacterial pathogens were organized into epithelial cells (epithelial cells). The process of IRAK-M was high. IRAK-M immunosuppressant molecules were known to be negative in one week, and the immune response was low in all tissues. One end of the infection is caused by chronic infection.

项目成果

ヒト歯肉上皮細胞のケモカイン産生におけるIRAK-M の関与

IRAK-M 参与人牙龈上皮细胞趋化因子的产生

• 发表时间: 2008
• 作者: Okada Y;Imendra KG;Miyazaki T;Hotokezaka H;Fujiyama R;Zeredo JL;Toda K;高橋直紀,本田朋之,奥井隆文,土門久哲,吉江弘正,多部田康一,山崎和久
• 通讯作者: 高橋直紀,本田朋之,奥井隆文,土門久哲,吉江弘正,多部田康一,山崎和久

Differential induction of interleukin-1 receptor-associated kinase-M in THP-1 cells by lipopolysaccharide derived from Porphyromonas gingivalis

牙龈卟啉单胞菌脂多糖对 THP-1 细胞中白细胞介素 1 受体相关激酶 M 的差异诱导

• 发表时间: 2007
• 作者: Domon H;Honda T;Oda T;Yamazaki K
• 通讯作者: Yamazaki K

Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease

• DOI: 10.1016/j.cca.2008.06.003
• 发表时间: 2008-09-01
• 期刊: CLINICA CHIMICA ACTA
• 影响因子: 5
• 作者: Honda, Tomoyuki;Aoki, Yukari;Yamazaki, Kazuhisa
• 通讯作者: Yamazaki, Kazuhisa

Up-regulation of the endoplasmic reticulum stress-response in periodontal disease

• DOI: 10.1016/j.cca.2008.12.007
• 发表时间: 2009-03-01
• 期刊: CLINICA CHIMICA ACTA
• 影响因子: 5
• 作者: Domon, Hisanori;Takahashi, Naoki;Yamazaki, Kazuhisa
• 通讯作者: Yamazaki, Kazuhisa

Early and preferential induction of IL-1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis

• DOI: 10.1189/jlb.0607432
• 发表时间: 2008-03-01
• 期刊: JOURNAL OF LEUKOCYTE BIOLOGY
• 影响因子: 5.5
• 作者: Domon, Hisanori;Honda, Tomoyuki;Yamazaki, Kazuhisa
• 通讯作者: Yamazaki, Kazuhisa