The role of interactions between IL-17 and periodontopathic bacteria in the pathogenesis of periodontitis

IL-17与牙周病细菌的相互作用在牙周炎发病机制中的作用

• 批准号: 23792470
• 负责人: HONDA Tomoyuki
• 金额: $ 2.75万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792470/
• 关键词: 歯肉上皮細胞; IL-17; IL-17R; Porphyromonas gingivalis; IL-17A; 炎症性サイトカイン; TNF-α

In human gingival epithelial cell lines, Epi4 cells, IL-17 up-regulated inflammatory cytokines and chemokines including CXCL8. IL-17, as well as TNF-α, is involved in the regulation of the innate immune response in gingival epithelial cells. Further studies are needed to examine the roles of interactions among periodontopathic bacteria, IL-17A and IL-17C in the pathogenesis of periodontitis.

在人牙龈上皮细胞系中，Epi 4细胞、IL-17上调炎性细胞因子和趋化因子，包括CXCL 8。IL-17和TNF-α参与调节牙龈上皮细胞的先天性免疫应答。牙周致病菌、IL-17 A和IL-17 C之间的相互作用在牙周炎发病机制中的作用有待进一步研究。

项目成果

Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis

牙周炎血清牙龈卟啉单胞菌抗体滴度与hs-CRP水平的关系

• 发表时间: 2012
• 期刊: Arch Oral Biol
• 影响因子: 3
• 作者: Miyashita H;Nakajima T;Tabeta K;Yamazaki K;他4名
• 通讯作者: 他4名

Porphyromonas gingivalis LPS が microRNA 発現に及ぼす影響

牙龈卟啉单胞菌LPS对microRNA表达的影响

• 发表时间: 2011
• 作者: Koichi Tabeta;Noriko Sugita and Hiromasa Yoshie;本田朋之,高橋直紀,宮内小百合,奥井隆文,多部田康一,中島貴子,山崎和久
• 通讯作者: 本田朋之,高橋直紀,宮内小百合,奥井隆文,多部田康一,中島貴子,山崎和久

Periostin up-regulated by Th2 cytokines promotes periodontal inflammation

Th2细胞因子上调骨膜素促进牙周炎症

• 发表时间: 2013
• 作者: Honda T;Miyauchi S;Ozawa M;Murakami S;Yamazaki K
• 通讯作者: Yamazaki K

Effect of interleukin-17 on the expression of chemokines in gingival epithelial cells

• DOI: 10.1111/j.1600-0722.2011.00842.x
• 发表时间: 2011-10-01
• 期刊: EUROPEAN JOURNAL OF ORAL SCIENCES
• 影响因子: 1.9
• 作者: Takahashi, Naoki;Okui, Takafumi;Yamazaki, Kazuhisa
• 通讯作者: Yamazaki, Kazuhisa

Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration

• DOI: 10.1016/j.cca.2011.09.023
• 发表时间: 2012-01-18
• 期刊: CLINICA CHIMICA ACTA
• 影响因子: 5
• 作者: Miyazawa, Haruna;Honda, Tomoyuki;Yamazaki, Kazuhisa
• 通讯作者: Yamazaki, Kazuhisa