Theoretical study on the regeneration of neuronal circuits during rehabilitation

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For the improvement of the outcome of rehabilitation after nerve injury, it is important to understand the mechanism underlying the organization of synaptic circuits. Therefore, this study has analyzed by developing a cortical pyramidal neuron model the influences of NMDA receptor (NMDAR) subunit expression and GABA inhibition, which are modulated through the nerve injury, on the organization process. The results have shown that the coordinated action of the NMDAR and GABA functions can regulate the fundamental properties of organization such as the balance between long-term potentiation and depression, the Hebbian effects, and the synaptic competition.