Establishment of inbred strains in zebrafish

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Zebrafish is a small fresh water fish which is one of the excellent model animals, especially for the developmental biology. Yet, there is no inbred strain in zebrafish. Since the genetic homogeneity of inbred strain improves the precision of analyses, the lack of inbred strains is a big disadvantage for zebrafish. Here, I have tried to inbreed two zebrafish wild-type strains through full sib-pair mating. Though one strain was failed to be succeeded after 13^<th> generation, the other strain has reached to breeding larvae of 20^<th> generation, which fulfills the definition of inbred strains.