The effect of inhaled Di (2-ethylhexyl) phthalate exposued to prepubertal or pregnant female rats for the reproductive function and pharmacokinetics.

我评价了吸入邻苯二甲酸二（2-乙基己基）酯（DEHP）对未成熟雌性大鼠生殖的影响和对下一代的影响。已明确，未成熟雌性大鼠通过吸入暴露于DEHP可能会提前青春期开始并改变青春期后生殖功能。妊娠大鼠吸入DEHP后，胎鼠体重下降，睾丸睾酮浓度及mRNA表达降低。

I evaluated the effects of inhaled Di(2-ethylhexyl)phthalate(DEHP) on the reproductive of immature female rats and next-generation effects. It was cleared that DEHP exposure via inhalation for immature female rats may advance puberty onset and alter postpubertal reproductive functions. In the study of DEHP inhalation for pregnant rats, fetal body weight was decreased and fetal testicular testosterone concentration and the expression of mRNA were also decreased.