Analysis of cross talk between human glioma cells and endothelial cells, and molecular targeted therapy

人胶质瘤细胞与内皮细胞之间的串扰分析及分子靶向治疗

• 批准号: 19591690
• 负责人: ABE Tatsuya
• 金额: $ 2.83万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591690/
• 关键词: 脳腫瘍; 血管内皮細胞; 幹細胞; クロストーク; 分子標的治療

Malignant brain tumor, such as glioblastoma, showed prominent angiogenesis, however tumor cells were growing without sufficient blood supply under hypoxic condition. The solid tumor, which showed the low sensitivity to chemoradiotherapy, led to a less favorable outcome, recurrence and poor prognosis. We previously have focused on hypoxia-inducible factor1α (HIF1α), transcription factor which worked under hypoxic condition. Recently, HIF1α induced the expression of stromal cell-derived factor-1(SDF-1) and its receptor, CXCR4 gene. SDF-1 recruits CXCR4-positive stem cells and progenitor cell, and repairs the tissue damaged by hypoxia. These reactions are necessary for the tumors to survive under hypoxic condition. In addition, such hypoxic microenvironment regulates the tumor characteristics. Therefore, we analyzed the cross talk between human glioma cells and endothelial cells, and investigated the molecular targeted therapy. We aimed to control the stem cell under hypoxic condition and apply to the future medical treatment.

恶性脑肿瘤，如胶质母细胞瘤，表现出明显的血管生成，但肿瘤细胞生长在缺氧条件下没有足够的血液供应。实体瘤对放化疗敏感性低，预后差，易复发。低氧诱导因子1 α（hypoxia-induciblefactor 1 α，HIF 1 α）是一种在低氧条件下发挥作用的转录因子。近年来，HIF 1 α诱导基质细胞衍生因子-1（SDF-1）及其受体CXCR 4基因表达。SDF-1募集CXCR 4阳性干细胞和祖细胞，修复缺氧损伤的组织。这些反应是肿瘤在缺氧条件下生存所必需的。此外，这种缺氧微环境调节肿瘤特性。因此，我们分析了人脑胶质瘤细胞与内皮细胞之间的相互作用，并对分子靶向治疗进行了研究。我们的目标是在缺氧条件下控制干细胞，并应用于未来的医疗。

项目成果

術中モニタリングを併用した深部脳腫瘍定位的生検術の検討脳腫瘍の外科-(原岡襄編)

深部脑肿瘤立体定向活检结合术中监测脑肿瘤手术（Jo Haraoka 编辑）

• 发表时间: 2010
• 期刊: なるにあ出版 (印刷中)
• 作者: 大場寛、阿部竜也;他
• 通讯作者: 他

Pilomyxoid astrocytoma: An immunohistologic study and review.

Pilomyxoid 星形细胞瘤：免疫组织学研究和综述。

• 发表时间: 2008
• 期刊: Neurosurgery Quarterly 18巻
• 作者: Abe T;他
• 通讯作者: 他

Juvenile cerebral infarction owing to cervicocephalic fibromusculardysplasia.

颈椎纤维肌性发育不良导致青少年脑梗死。

• 发表时间: 2008
• 期刊: Neurosurgery Quarterly 18
• 作者: Wakabayashi Y;Ishii K;Murata;K;Ohba H;Kamida T;Hikawa T;Abe T;Kobayashi H.
• 通讯作者: Kobayashi H.

Unique Infiltrating Morphology of Meningioma

脑膜瘤独特的浸润形态

• 发表时间: 2007
• 期刊: Surgical Neurology 68
• 作者: Ooba H;Abe T;Wakabayashi Y;Kamida T;Ishii K;Fujiki M;Kobayashi H;Asano T;Hori Y;Nagatomi H.
• 通讯作者: Nagatomi H.

Navigated Brain Stimulation for Preoperative Anatomic and functional identification of impaired motor cortex in a patient with meningioma

导航脑刺激用于术前识别脑膜瘤患者运动皮层受损的解剖学和功能

• 发表时间: 2007
• 期刊: Neurosurgery Quarterly 149
• 作者: Fujiki M;Hikawa T;Abe T;Anan M;Sugita K;Kobayashi H
• 通讯作者: Kobayashi H