Analysis of early degenerative changes of arthritis cartilage

关节炎软骨早期退行性改变分析

• 批准号: 19591758
• 负责人: OKAZAKI Ken
• 金额: $ 2.83万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591758/
• 关键词: 臨床; 関節炎; 生体分子; 発現制御; 変形性関節症; 軟骨変性; 早期診断; MRI; 軟骨

We established the parameter for T1rho mapping sequences of magnetic resonance image to detect the degenerative cartilage, in particular, the loss of proteoglycan in the arthritis cartilage. The signal intensity of T1 rho mapping is correlated with the value of degeneration of arthritis cartilage. It is also correlated with the histological score of the cartilage. We also established a new simplified sequence for T1 rho mapping. The entire imaging time required for sT1p maps (6min 30s) was three-fifths shorter than that of the cT1p map (16min 15s). The image quality of the sT1p map_1_40 and of the sT1p map_1_80 was the similar to that of the cT1p map (Fig.1). The simplified T1p calculation method has the same potential as the conventional method to diagnose articular cartilage. We speculate that it would be appropriate to select two T1p prepared images using the shortest and longest TSLs. However, the image quality would be poor if images using long TSLs only were selected because long TSL may decrease the signal-to-noise ratio of T1p prepared image.

我们建立了磁共振T1rho成像序列的参数，以检测退行性软骨，特别是关节炎软骨中蛋白多糖的丢失。T1rho信号强度与关节软骨退变程度相关。它还与软骨的组织学评分相关。我们还建立了一个新的简化序列的T1 ρ映射。sT1p图所需的整个成像时间（6分30秒）比cT1p图（16分15秒）短五分之三。sT1p图_1_40和sT1p图_1_80的图像质量与cT1p图的图像质量相似（图1）。简化的T1p计算方法具有与诊断关节软骨的常规方法相同的潜力。我们推测，使用最短和最长TSL选择两个T1p准备图像是合适的。然而，如果仅选择使用长TSL的图像，则图像质量会很差，因为长TSL可能会降低T1p准备图像的信噪比。

项目成果

Three-dimensional analysis of computed tomography-based navigation system for total knee arthroplasty: the accuracy of computed tomography-based navigation system.

全膝关节置换术计算机断层扫描导航系统的三维分析：计算机断层扫描导航系统的准确性。

• DOI: 10.1016/j.arth.2008.07.007
• 发表时间: 2009
• 期刊: The Journal of arthroplasty
• 作者: H. Mizu;S. Matsuda;H. Miura;H. Higaki;K. Okazaki;Y. Iwamoto
• 通讯作者: Y. Iwamoto

Quantitative assessment of rotatory instability after an anterior cruciate ligament reconstruction : Measurement using an open magnetic resonance imaging system

前交叉韧带重建后旋转不稳定性的定量评估：使用开放式磁共振成像系统进行测量

• 发表时间: 2009
• 期刊: Am J Sports Med 37
• 作者: Tashiro Y;Okazaki K;Miura H;Nakanishi Y;Iwamoto Y
• 通讯作者: Iwamoto Y

転写因子C/EBPβは関節炎での様々な炎症誘因反応を調節する多機能因子である

转录因子 C/EBPβ 是调节关节炎中各种促炎反应的多功能因子

• 发表时间: 2009
• 作者: 岡崎賢;林田光正;岩本幸英
• 通讯作者: 岩本幸英

MRIによる膝関節軟骨基質評価の関節リウマチへの応用

MRI评估膝关节软骨基质在类风湿性关节炎中的应用

• 发表时间: 2007
• 作者: 岡崎賢;安永武史;中島康晴;馬渡太郎;福士純一;橋爪誠;岩本幸英
• 通讯作者: 岩本幸英

Iwamoto Y Comparative histopathological analysis between tenosynovitis and joint synovitis in rheumatoid arthritis

Iwamoto Y 类风湿性关节炎腱鞘炎与关节滑膜炎的组织病理学比较分析

• 发表时间: 2008
• 期刊: Histopathology 52(7)
• 作者: Kaibara N;Yamada H;Shuto T;Nakashima Y;Okazaki K;Miyahara H;Esaki Y;Hirata G
• 通讯作者: Hirata G