Basic and clinical research for tailored chemotherapy aiming tumor dormancy of advanced and recurred ovarian cancers
Basic and clinical research for tailored chemotherapy aiming tumor dormancy of advanced and recurred ovarian cancers
批准号:
19591936
负责人:
KOBAYASHI Hiroaki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
血管内皮細胞が少量の抗癌剤でも再現性良く障害されることに着目し、抗癌剤を少量頻回持続投与することで軽い副作用のままにがんを休眠状態に導こうというメトロノミック化学療法の有用性の検討を行った。ヒト卵巣がん由来の薬剤耐性腫瘍を用いた動物実験で、軽度の副作用にも関わらずがん休眠状態に導きやすいことが確認できた。臨床試験でも少数例ながら癌の進行を食い止めたと考えられる症例が得られ、治療中のQOLは良好であった。以上、基礎的にも臨床的にも今回のがん休眠化学療法の有効性が示唆された。
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DOI:
--
发表时间:
2008
期刊:
Pathology international 58(4)
影响因子:
--
作者:
[Yasunaga, M., Ohishi , Y., Nishimura, I.,Tamiya, S., Iwasa, A. , Takagi , E., Inoue,T., Yahata, H., Kobayashi, H., Wake, N. ,Tsuneyoshi, M.]
通讯作者:
M.
DOI:
10.1016/j.ygyno.2008.12.027
发表时间:
2009-04-01
期刊:
GYNECOLOGIC ONCOLOGY
影响因子:
4.7
作者:
[Onda, Takashi, Kobayashi, Hiroaki, Yoshikawa, Hiroyuki]
通讯作者:
Yoshikawa, Hiroyuki
DOI:
10.1016/j.ygyno.2007.05.020
发表时间:
2007-10-01
期刊:
GYNECOLOGIC ONCOLOGY
影响因子:
4.7
作者:
[Ohishi, Yoshihiro, Kaku, Tsunehisa, Tsuneyoshi, Masazumi]
通讯作者:
Tsuneyoshi, Masazumi
DOI:
10.1111/j.1440-1827.2008.02307.x
发表时间:
2008-12-01
期刊:
PATHOLOGY INTERNATIONAL
影响因子:
2.2
作者:
[Iwasa, Atsuko, Oda, Yoshinao, Tsuneyoshi, Masazumi]
通讯作者:
Tsuneyoshi, Masazumi
Biologic Significance of Receptor-binding Cancer Antigen Expressedon SiSo Cells (RCASl) as a Pivotal Regulator of Tumor Growth Through Angiogenesis in Human Uterine Cancer
SiSo 细胞 (RCAS1) 表达的受体结合癌抗原作为人子宫癌中通过血管生成促进肿瘤生长的关键调节因子的生物学意义
DOI:
--
发表时间:
2007
期刊:
Cancer 110
影响因子:
--
作者:
[Sonoda, K., Kobayashi, H., et. al.]
通讯作者:
et. al.
共 21 条
Role of multifunctional matrix protein Thrombospondin-1 in periodontal disease
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批准号:16K11826
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
-
财政年份:2016
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负责人:KOBAYASHI Hiroaki
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依托单位:
Development of education program tailored for junior and senior high school students who stutter base on their need and lifestyle
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批准号:24653291
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.91万
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财政年份:2012
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负责人:KOBAYASHI Hiroaki
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依托单位:
Application-Aware Highly Hierarchical Memory Architecture
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批准号:24650018
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:KOBAYASHI Hiroaki
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依托单位:
Calponin h1-gene therapy using Tat-peptide vector against peritoneal dissemination of ovarian cancer
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批准号:24592520
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2012
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负责人:KOBAYASHI Hiroaki
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依托单位:
Development of the comprehensive assessment battery for children who stutter
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批准号:24330263
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.57万
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财政年份:2012
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负责人:KOBAYASHI Hiroaki
-
依托单位:
Mechanism of Th17 regulation based on TGF beta in progression of periodontits
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批准号:22792080
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.58万
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财政年份:2010
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负责人:KOBAYASHI Hiroaki
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依托单位:
Innovative 3D Design for the New Generation Vector Microarchitecture
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批准号:22300013
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.48万
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财政年份:2010
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负责人:KOBAYASHI Hiroaki
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依托单位:
Statistical evaluation of agricultural protection by food exporting countries and impacts on world food markets
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批准号:22580265
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.5万
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财政年份:2010
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负责人:KOBAYASHI Hiroaki
-
依托单位:
Development of comprehensive assessment battery for children who stutter
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批准号:21730716
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2009
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负责人:KOBAYASHI Hiroaki
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依托单位:
Study for the efficacy of'Metronomic chemotherapy' agains the gynecological cancers
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批准号:21592135
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2009
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负责人:KOBAYASHI Hiroaki
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依托单位:
Reinforcement Learning of Action Strategies and Joint Stiffness of Tendon-driven Biped Robot
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批准号:21560275
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.25万
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财政年份:2009
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负责人:KOBAYASHI Hiroaki
-
依托单位:
Mechanism of periodontal tissue destruction caused by Th17 axis.
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批准号:20791608
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2008
-
负责人:KOBAYASHI Hiroaki
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依托单位:
Export enhancing effect of domestic agricultural support by exporting countries : An econometric approach
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批准号:19580267
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.0万
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财政年份:2007
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负责人:KOBAYASHI Hiroaki
-
依托单位:
Study on Hardware-Software Collaborative Scheduling for Highly Efficient Multithreading
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批准号:18300011
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.71万
-
财政年份:2006
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负责人:KOBAYASHI Hiroaki
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依托单位:
Research for molecular mechanism and clinical application of calponin-gene therapy against Peritoneal dissemination of ovarian cancer
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批准号:17591747
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:KOBAYASHI Hiroaki
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依托单位:
Effects of FTA on Agricultural Trade : An Econometric Analysis by the Policy Evaluation Model
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批准号:16580190
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.73万
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财政年份:2004
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负责人:KOBAYASHI Hiroaki
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依托单位:
INTELLIGENT CONTROL OF TENDON-DRIVEN ROBOTIC MECHANISMS.
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批准号:15560225
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2003
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负责人:KOBAYASHI Hiroaki
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依托单位:
Safety assessment on team operation for shiphandling
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批准号:15360463
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2003
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负责人:KOBAYASHI Hiroaki
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依托单位:
A basic trial of gene therapy against peritoneal dissemination of ovarian cancer by calponin h1 gene transfer
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批准号:15591757
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:KOBAYASHI Hiroaki
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依托单位:
An Intelligent Memory Architecture for 3D Graphics
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批准号:14380132
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.25万
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财政年份:2002
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负责人:KOBAYASHI Hiroaki
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依托单位: