Basic and clinical research for tailored chemotherapy aiming tumor dormancy of advanced and recurred ovarian cancers

针对晚期和复发性卵巢癌肿瘤休眠的定制化疗的基础和临床研究

• 批准号: 19591936
• 负责人: KOBAYASHI Hiroaki
• 金额: $ 2.91万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591936/
• 关键词: がん休眠療法; テーラード化学療法; メトロノミック化学療法; 進行再発卵巣癌; がん休眠療

血管内皮細胞が少量の抗癌剤でも再現性良く障害されることに着目し、抗癌剤を少量頻回持続投与することで軽い副作用のままにがんを休眠状態に導こうというメトロノミック化学療法の有用性の検討を行った。ヒト卵巣がん由来の薬剤耐性腫瘍を用いた動物実験で、軽度の副作用にも関わらずがん休眠状態に導きやすいことが確認できた。臨床試験でも少数例ながら癌の進行を食い止めたと考えられる症例が得られ、治療中のQOLは良好であった。以上、基礎的にも臨床的にも今回のがん休眠化学療法の有効性が示唆された。

A small amount of vascular endothelial cells can be used for anti-cancer therapy, which can produce reproducible benign and harmful effects, and a small amount of anti-cancer therapy can be used frequently.とで軽い Side effects of chemotherapy and the usefulness of chemotherapy.ヒト egg 巣がん Origin の薬剤resistant tumor を Use いたanimal 実験で、軽度の Vice The function is to shut down the sleep state and confirm the status of the sleep state. Clinical trials have shown that a few cases of cancer have been treated, and the symptoms of cancer have been improved, and the quality of life during treatment has been good. The above is a basic clinical explanation of the effectiveness of dormant chemotherapy.

项目成果

Ovarian undifferentiated carcinoma resembling giant cell carcinoma of the lung

卵巢未分化癌类似肺巨细胞癌

• 发表时间: 2008
• 期刊: Pathology international 58(4)
• 作者: Yasunaga;M.;Ohishi ;Y.;Nishimura;I.,Tamiya;S.;Iwasa;A. ;Takagi ;E.;Inoue,T.;Yahata;H.;Kobayashi;H.;Wake;N. ,Tsuneyoshi;M.
• 通讯作者: M.

Feasibility study of neoadjuvant chemotherapy followed by interval debulking surgery for stage III/IV ovarian, tubal, and peritoneal cancers: Japan Clinical Oncology Group Study JCOG0206

• DOI: 10.1016/j.ygyno.2008.12.027
• 发表时间: 2009-04-01
• 期刊: GYNECOLOGIC ONCOLOGY
• 影响因子: 4.7
• 作者: Onda, Takashi;Kobayashi, Hiroaki;Yoshikawa, Hiroyuki
• 通讯作者: Yoshikawa, Hiroyuki

CD56 expression in ovarian granulosa cell tumors, and its diagnostic utility and pitfalls

• DOI: 10.1016/j.ygyno.2007.05.020
• 发表时间: 2007-10-01
• 期刊: GYNECOLOGIC ONCOLOGY
• 影响因子: 4.7
• 作者: Ohishi, Yoshihiro;Kaku, Tsunehisa;Tsuneyoshi, Masazumi
• 通讯作者: Tsuneyoshi, Masazumi

Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53-and p16/Rb-dependent cell cycle regulator proteins

• DOI: 10.1111/j.1440-1827.2008.02307.x
• 发表时间: 2008-12-01
• 期刊: PATHOLOGY INTERNATIONAL
• 影响因子: 2.2
• 作者: Iwasa, Atsuko;Oda, Yoshinao;Tsuneyoshi, Masazumi
• 通讯作者: Tsuneyoshi, Masazumi

Biologic Significance of Receptor-binding Cancer Antigen Expressedon SiSo Cells (RCASl) as a Pivotal Regulator of Tumor Growth Through Angiogenesis in Human Uterine Cancer

SiSo 细胞 (RCAS1) 表达的受体结合癌抗原作为人子宫癌中通过血管生成促进肿瘤生长的关键调节因子的生物学意义

• 发表时间: 2007
• 期刊: Cancer 110
• 作者: Sonoda;K.;Kobayashi;H.;et. al.
• 通讯作者: et. al.