A study on the cooperative regulation of bone metabolism between upper and lower jaw through the trigeminal ganglion

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For studying the cooperative regulation of bone metabolism between upper and lower jaw through the trigeminal ganglion, we examined the regulation system by using the cultured osteoblasts and the orthodontic tooth movement model for the rat upper molar. Our results demonstrated that the neurons for mandibular and maxilla secret the neuropeptides, such as substance P and neurokinin B, to regulate their bone metabolism through the activation of satellite cells around the neurons.