Regulation of CCN family gene expression via micro RNA regulatory network and its Biological signficance
Regulation of CCN family gene expression via micro RNA regulatory network and its Biological signficance
批准号:
19592142
负责人:
KUBOTA Satoshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
マイクロRNA(miRNA)は小分子noncoding RNA(ncRNA)であり、個々のmiRNAが数千のmRNAの3'非翻訳領域を標的として、遺伝子の発現をネットワーク的に制御する。本研究ではCCNファミリー遺伝子の代表的メンバーであり、間葉系組織の成長ならびに再生を指揮するCCN2遺伝子が特定のmiRNAの制御ネットワーク下にあることを実証した。さらに、このmiRNAによる制御が、軟骨細胞の成熟形質の獲得・維持に重要であることも明らかとなった。またmiRNAの作用機構や軟骨細胞後期分化における役割を今後解明していく上で、有用な知見をも得ることができた。
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Role of mechanical-stress induc ible protein HCS24/CTGF/CCN2 in carti-lage growth and regeneration
机械应力诱导蛋白HCS24/CTGF/CCN2在软骨生长和再生中的作用
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Takigawa, M.]
通讯作者:
M.
DOI:
10.1093/jb/mvn159
发表时间:
2009-02
期刊:
Journal of biochemistry
影响因子:
2.7
作者:
[Maeda A, Nishida T, Aoyama E, Kubota S, Lyons KM, Kuboki T, Takigawa M]
通讯作者:
Takigawa M
DOI:
10.1111/j.1742-4658.2007.05709.x
发表时间:
2007-04-01
期刊:
FEBS JOURNAL
影响因子:
5.4
作者:
[Yanagita, Takeshi, Kubota, Satoshi, Takigawa, Masaharu]
通讯作者:
Takigawa, Masaharu
DOI:
10.1161/hypertensionaha.106.077537
发表时间:
2007-05-01
期刊:
HYPERTENSION
影响因子:
8.3
作者:
[Koitabashi, Norimichi, Arai, Masashi, Kurabayashi, Masahiko]
通讯作者:
Kurabayashi, Masahiko
癌顎骨切除標本におけるCCN2の臨床病理学的検討
癌颌骨切除标本中CCN2的临床病理学检查
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[志茂 剛, 他]
通讯作者:
他
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Investigation of the intracellular function of human ecogenin/CTGF, a chondrocyte-derived growth factor.
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依托单位: