Development and medical application of peptide and RNA aptamers that bind to CCN2
Development and medical application of peptide and RNA aptamers that bind to CCN2
批准号:
21592360
负责人:
KUBOTA Satoshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
CCN2 is known to promote harmonized regeneration of bone and cartilage tissues and to be involved in fibrotic disorders of a variety of organs. Therefore, regulating CCN2 function is of great significance in the field of regenerative medicine and fibrosis therapeutics. In this study, we designed, synthesized and evaluated the effect of aptamers that bind to CCN2, in order to control the molecular action of CCN2. As a result, we could obtain a few aptamers that could promote cartilage regeneration, or might regulate bone remodeling.
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DOI:
10.1016/j.bone.2011.06.033
发表时间:
2011-11-01
期刊:
BONE
影响因子:
4.1
作者:
[Kawaki, Harumi, Kubota, Satoshi, Takigawa, Masaharu]
通讯作者:
Takigawa, Masaharu
Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3. in CCN Proteins in Health and Disease. A. Perbal, M. Takigawa & B. Perbal(eds)
CCN2 和 CCN3 协同调节细胞增殖和分化。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Takigawa M., et al.]
通讯作者:
et al.
DOI:
10.1172/jci44957
发表时间:
2011-08-01
期刊:
JOURNAL OF CLINICAL INVESTIGATION
影响因子:
15.9
作者:
[Kodama, Takahiro, Takehara, Tetsuo, Hayashi, Norio]
通讯作者:
Hayashi, Norio
解糖経路の阻害は重篤な軟骨変性を引き起す
糖酵解途径的抑制导致严重的软骨退化
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[西田崇, 他]
通讯作者:
他
遺伝子発現の転写後調節の重要性:組織再生因子CCN2の場合
基因表达转录后调控的重要性:以组织再生因子CCN2为例
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[西田崇, 他, 久保田聡]
通讯作者:
久保田聡
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