Molecular cloning and functional analysis of non-coding RNA expressed in periodontal bacteria
Molecular cloning and functional analysis of non-coding RNA expressed in periodontal bacteria
批准号:
19592387
负责人:
MAEDA Hiroshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
歯周病の原因となる細菌(歯周病細菌)における、非翻訳RNAの役割を解析することを目的として、以下の研究成果を得た。(1) 歯周病細菌Aggregatibacter actinomycetetemcomitansに大腸菌と類似した非翻訳RNAが発現していることを示した。(2) A. actinomycetemcomitansからRNAシャペロンを同定し、クローニングした。(3) RNAシャペロンを介した非翻訳RNAによる遺伝子発現調節機構がA. actinomycetemcomitansに存在する可能性を示した。(4)歯周病の病態には細菌だけでなく古細菌種が関与しており、その解析の必要性を示した。
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