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Identification of a novel nutrient signal related on health and longevity : role in the prevention of common diseases.

Identification of a novel nutrient signal related on health and longevity : role in the prevention of common diseases.
鉴定与健康和长寿相关的新型营养信号：在预防常见疾病中的作用。
批准号：
19680030
负责人：
TAKETANI Yutaka
金额：
$10.32万
依托单位：
The University of Tokushima
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (A)
财政年份：
2007
资助国家：
日本
项目状态：
已结题
起止时间：
2007 至 2009
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19680030/
关键词：
シグナル伝達リン血管内皮細胞高リン血症心血管疾患慢性腎臓病予防栄養学血管内皮機能血管内皮

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中文摘要
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英文摘要
Nutrients and their metabolites are balanced within adequate levels to maintain normal physiological functions. Impairment of the balance of nutrient metabolism by unfavorable diet causes life-style related diseases such as diabetes, cardiovascular disease, etc. In this research, we investigated the role of nutrient signal, especially focused on "phosphate signal" that is closely related on aging and some life-style related diseases. Hyperphosphatemia caused by high phosphate intake can induce endothelial dysfunction through the phosphate signal, and it would be a risk factor for cardiovascular cliseaSe.
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Advantage of low glycemie index and low phosphate diet on diabetic nephropathy and aging-related diseases.
低血糖指数和低磷饮食对糖尿病肾病和衰老相关疾病的优势。
DOI： --
发表时间： 2007
期刊： J Med Invest 54
影响因子： --
作者： [Taketani Y, Shuto E, Nishida Y, Tanaka R.]
通讯作者： Tanaka R.
Involvement of cell surface ATP synthase in flow-induced ATP release by vascular endothelial cells.
DOI： 10.1152/ajpheart.01385.2006
发表时间： 2007-09
期刊： American journal of physiology. Heart and circulatory physiology
影响因子： --
作者： [Kimiko Yamamoto;N. Shimizu;S. Obi;S. Kumagaya;Y. Taketani;A. Kamiya;J. Ando]
通讯作者： Kimiko Yamamoto;N. Shimizu;S. Obi;S. Kumagaya;Y. Taketani;A. Kamiya;J. Ando
Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts
DOI： 10.1016/j.bone.2007.02.030
发表时间： 2007-07-01
期刊： BONE
影响因子： 4.1
作者： [Sawada, Naoki, Taketani, Yutaka, Takeda, Eiji]
通讯作者： Takeda, Eiji
Dietary palatinose and oleic acid ameliorates disorders of glucose and lipidMetabolism in Zucker Fatty Rats.
膳食帕拉金糖和油酸可改善 Zucker 肥胖大鼠的葡萄糖和脂质代谢紊乱。
DOI： --
发表时间： 2007
期刊： Journal of Nutrition 137
影响因子： --
作者： [中村厚, 永岡隆, 古川雅代, 野村将大, 鈴木麻悌, 大里奈央, 松村あずさ, 大坪真也, 會沢勝夫, 清原祥夫, 伊藤祥輔, 若松一雅, 宗田孝之, Sato K]
通讯作者： Sato K
共 29 条
    Elucidation of set-point mechanism for phosphate homeostasis and development of a novel therapeutic target for age-related diseases
    • 批准号：
      19H04053
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $11.15万
    • 财政年份：
      2019
    • 负责人：
      TAKETANI Yutaka
    • 依托单位：
      The University of Tokushima
    Elucidation of mechanism for serum phosphate homeostasis regulated by excercise and application for prevention and treatment of CKD-MBD
    • 批准号：
      19K22811
    • 项目类别：
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额：
      $4.16万
    • 财政年份：
      2019
    • 负责人：
      TAKETANI Yutaka
    • 依托单位：
      The University of Tokushima
    Establishment of a novel research strategy for dietetics based on epigenomics (epigenome dietetics)
    • 批准号：
      16H03046
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.9万
    • 财政年份：
      2016
    • 负责人：
      TAKETANI Yutaka
    • 依托单位：
      The University of Tokushima
    Identification of sensory mechanism of dietary phosphorus and pathophysiology of impaired early secretion of parathyroid hormone.
    • 批准号：
      26560057
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.33万
    • 财政年份：
      2014
    • 负责人：
      TAKETANI Yutaka
    • 依托单位：
      The University of Tokushima
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