Identification of a novel nutrient signal related on health and longevity : role in the prevention of common diseases.

鉴定与健康和长寿相关的新型营养信号：在预防常见疾病中的作用。

• 批准号: 19680030
• 负责人: TAKETANI Yutaka
• 金额: $ 10.32万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19680030/
• 关键词: シグナル伝達; リン; 血管内皮細胞; 高リン血症; 心血管疾患; 慢性腎臓病; 予防栄養学; 血管内皮機能; 血管内皮

Nutrients and their metabolites are balanced within adequate levels to maintain normal physiological functions. Impairment of the balance of nutrient metabolism by unfavorable diet causes life-style related diseases such as diabetes, cardiovascular disease, etc. In this research, we investigated the role of nutrient signal, especially focused on "phosphate signal" that is closely related on aging and some life-style related diseases. Hyperphosphatemia caused by high phosphate intake can induce endothelial dysfunction through the phosphate signal, and it would be a risk factor for cardiovascular cliseaSe.

营养素及其代谢物在足够的水平内平衡，以维持正常的生理功能。不良饮食导致营养代谢平衡受损，导致糖尿病、心血管疾病等生活方式相关疾病的发生。本研究探讨了营养信号的作用，特别是与衰老和生活方式相关疾病密切相关的“磷酸信号”。高磷血症可通过磷酸盐信号介导内皮功能障碍，是心血管疾病的危险因素。

项目成果

Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts

• DOI: 10.1016/j.bone.2007.02.030
• 发表时间: 2007-07-01
• 期刊: BONE
• 影响因子: 4.1
• 作者: Sawada, Naoki;Taketani, Yutaka;Takeda, Eiji
• 通讯作者: Takeda, Eiji

Advantage of low glycemie index and low phosphate diet on diabetic nephropathy and aging-related diseases.

低血糖指数和低磷饮食对糖尿病肾病和衰老相关疾病的优势。

• 发表时间: 2007
• 期刊: J Med Invest 54
• 作者: Taketani Y;Shuto E;Nishida Y;Tanaka R.
• 通讯作者: Tanaka R.

Involvement of cell surface ATP synthase in flow-induced ATP release by vascular endothelial cells.

• DOI: 10.1152/ajpheart.01385.2006
• 发表时间: 2007-09
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Kimiko Yamamoto;N. Shimizu;S. Obi;S. Kumagaya;Y. Taketani;A. Kamiya;J. Ando

Dietary palatinose and oleic acid ameliorates disorders of glucose and lipidMetabolism in Zucker Fatty Rats.

膳食帕拉金糖和油酸可改善 Zucker 肥胖大鼠的葡萄糖和脂质代谢紊乱。

• 发表时间: 2007
• 期刊: Journal of Nutrition 137
• 作者: 中村厚;永岡隆;古川雅代;野村将大;鈴木麻悌;大里奈央;松村あずさ;大坪真也;會沢勝夫;清原祥夫;伊藤祥輔;若松一雅;宗田孝之;Sato K
• 通讯作者: Sato K

最新トランスポーター研究2009

2009 年最新转运蛋白研究

• 发表时间: 2009
• 作者: 宮本賢一;他
• 通讯作者: 他