Establishment of research basis for nutrigenomics-based nutritional education

建立基于营养基因组学的营养教育研究基础

• 批准号: 22650181
• 负责人: TAKETANI Yutaka
• 金额: $ 2.07万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650181/
• 关键词: 栄養学; 食品; 循環器疾患; 食育; リン; 遺伝因子; 生活習慣病

In this study, we attempted to establish a strategy to development a new procedure for nutritional education based on molecular nutrition with genetic factors affecting eating habits, behaviors, and pathogenesis of life-style related diseases. As a representative research model, we investigated the relationships between genetic factors and dietary phosphate intake, post-prandial serum P levels, endothelial function, and appetite. Our results suggest that our strategy was effective to analyze the individual differences in the relationships between dietary intake and nutrient metabolism, eating behavior, serum markers, or patho-physiological function with genetic factors. The strategy may enable us to develop a tailor-made strategy of nutritional education to prevent various life-style related diseases.

在这项研究中，我们试图建立一个战略，开发一个新的程序，营养教育的基础上，分子营养与遗传因素影响饮食习惯，行为和生活方式相关疾病的发病机制。作为一个有代表性的研究模型，我们调查了遗传因素与膳食磷酸盐摄入量、餐后血清P水平、内皮功能和食欲之间的关系。我们的研究结果表明，我们的策略是有效的，以分析膳食摄入量和营养代谢，饮食行为，血清标志物，或病理生理功能与遗传因素之间的关系的个体差异。该策略可能使我们能够制定量身定制的营养教育策略，以预防各种与生活方式相关的疾病。

项目成果

Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet

• DOI: 10.1016/j.jnutbio.2011.03.023
• 发表时间: 2012-07-01
• 期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY
• 影响因子: 5.6
• 作者: Uebanso, Takashi;Taketani, Yutaka;Takeda, Eiji
• 通讯作者: Takeda, Eiji

栄養学的に見た高リン血症の問題

从营养角度看高磷血症问题

• 发表时间: 2010
• 作者: Matsuda S;Yoshida H;et al.;竹谷豊
• 通讯作者: 竹谷豊

慢性腎臓病における高リン血症と心血管疾患

慢性肾病中的高磷血症和心血管疾病

• 发表时间: 2011
• 作者: 竹谷豊;他
• 通讯作者: 他