Molecular basisfor the integral regulatory system ofnutritional homeostasis and its role in the life-style related diseases.

点击翻译按钮获取中文摘要

Although molecular mechanisms for life-style related diseases have been clarified, interaction between nutrients has not been elucidated yet. In this study, we attempted to understand how disturbance of phosphorus metabolism can affect energy metabolism, resulted in various life-style related diseases including obesity, atherosclerosis, diabetes. Here, we identified key molecules to regulate both phosphorus and energy metabolism in cellular levels. In addition, we found that disturbance of phosphorus metabolism can affect energy expenditure and endothelial function in animal model and human study.