皮膚筋炎/多発性筋炎の新規自己抗体の同定

皮肌炎/多发性肌炎新型自身抗体的鉴定

• 批准号: 25860940
• 负责人: 吉村 紫
• 金额: $ 1.66万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860940/
• 关键词: 皮膚筋炎; 臨床; 自己抗体

1996-2012年の間に，当施設で経験した皮膚筋炎患者74例を対象とした。抗Jo-1抗体，抗EJ抗体，抗PL-7抗体，抗PL-12抗体，抗OJ抗体，抗SRP抗体，抗Mi-2抗体，抗MDA5抗体，抗p155/140抗体，抗MJ抗体，抗SAE抗体の標準血清と比較検討を行いながら免疫沈降法にて対応抗原の同定を行った。74例中56例が上記の抗体に該当し，主に抗Mi-2抗体，抗MDA5抗体，抗p155/140抗体，抗ARS抗体の4群に分類された。次にこれらのグループ間で背景，臨床症状，皮疹，悪性腫瘍の合併，間質性肺炎，予後や治療反応性について比較検討を行ったが，背景，皮疹，治療反応性，臨床症状については4群間で有意差はみられなかったが，悪性腫瘍の合併，予後（死亡率）は抗p155/140抗体を有する群で有意差があった。さらに抗p155/140抗体陽性群において悪性腫瘍合併群と非合併群の２群に分け，臨床症状，皮疹，悪性腫瘍の合併，間質性肺炎，予後や治療反応性について同様に比較検討した。悪性腫瘍合併群の方が，高齢で，罹病期間が短く，生存率が低いことが分かった。最後に，特異抗体の検出できなかった18例において，免疫沈降法を再度行い共通するバンドがあるかどうかを検討したが，今回の実験では確認できなかった。

1996-2012 During the year, 74 patients with dermatotendinitis were treated. Standard serum and comparative studies of anti-Jo-1 antibody, anti-EJ antibody, anti-PL-7 antibody, anti-PL-12 antibody, anti-OJ antibody, anti-SRP antibody, anti-Mi-2 antibody, anti-MDA5 antibody, anti-p155/140 antibody, anti-MJ antibody, and anti-SAE antibody can be carried out to determine the identity of antigens in the immunosedimentation method. Among 74 cases, 56 cases had antibodies listed above, mainly anti-Mi-2 antibody, anti-MDA 5 antibody, anti-p155/140 antibody and anti-ARS antibody. Background, clinical symptoms, rash, combination of malignant tumors, interstitial pneumonia, treatment response, background, rash, treatment response, clinical symptoms, intentional differences between 4 groups, intentional differences, intentional differences between 4 groups, intentional differences, intentional differences between 4 groups, intentional differences, intentional differences between 4 groups, intentional differences, intentional differences, and intentional differences between 4 groups, intentional differences, intentional differences between 4 groups, intentional differences, intentional differences In addition, the anti-p155/140 antibody positive group was divided into two groups: the combined group and the non-combined group. The clinical symptoms, rash, combined group and interstitial pneumonia were compared. The disease duration is short, and the survival rate is low. Finally, the detection of specific antibodies in 18 cases, immunoprecipitation method again in common, this time it is confirmed.