Pleiotropic effects of dietary antioxidants against atherosclerosis progression

我们研究了膳食抗氧化剂，如多酚、类胡萝卜素、维生素C和维生素E，对内皮功能障碍、巨噬细胞激活和脂肪细胞分化的影响。膳食抗氧化剂可降低内皮细胞的活性氧生成、炎症细胞因子表达和单核细胞粘附。它们抑制MMP分泌、清道夫受体表达和泡沫细胞形成，并抑制脂肪细胞分化。这些结果表明，膳食抗氧化剂对动脉粥样硬化进展的多效性作用超出了其抗氧化能力。

We investigated the effects of dietary antioxidants, such as polyphenols, carotenoids, vitamin C and vitamin E, on endothelial dysfunction, macrophage activation, and adipocyte differentiation. Dietary antioxidants decreased reactive oxygen species production, inflammatory cytokines expression and monocyte adhesion in endothelial cells. They inhibited MMP secretion, scavenger receptors expression and foam cell formation and also suppressed adipocyte differentiation. These results showed the pleiotropic effects of dietary antioxidants against atherosclerosis progression beyond their antioxidative potency.