Studies on Molecular Science of Biologically Active Natural Products Based on Chemical Synthesis

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To advance studies on molecular science of triterpene polyethers and alkaloids, biologically active natural products(secondary metabolites from organisms), their chemical syntheses were carried out. As a result, we have succeeded in determining the entire stereostructure of omaezakianol by the asymmetric total synthesis, developing the chemical synthesis method of isodehydrothyrsiferol, and chemically reproducing biomimetic oxacyclizations of teurilene and ekeberin D_4.In addition, an efficient synthesis of the indeno-tetrahydropyridine skeleton of houamine B has also been accomplished.