Novel functions of evolutionarily conserved calpain-7/PalBH in membrane trafficking system.

钙蛋白酶在人类中由15个基因编码，构成一个细胞内依赖于钙的蛋白水解酶家族。它们的功能是保护活的生物体，因此，钙蛋白酶功能的缺陷会导致致命性疾病或肌肉营养不良等疾病。在这项研究中，我们重点研究了从人到酵母都保守的calain-7/PalBH，但到目前为止还没有得到很好的研究。因此，研究表明，与calain-2和-3一样，calain-7在哺乳动物生命中也扮演着重要的角色。

Calpains, which are encoded by 15 genes in humans, constitute a family of intracellular Ca^<2+>-dependent proteases. They function to protect living organisms, and, therefore, defects in calpain functions result in lethality or diseases like muscular dystrophy. In this study, we focused on calpain-7/PalBH, which is conserved from human to yeast but has not been studied well so far. As a result, it was suggested that calpain-7 also plays essential roles for mammalian life like calpain-2 and-3.