Targeted therapy for defect of fertilizing ability in the spermatozoa from subfertile livestock

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The initial step of animal reproduction is accomplishment of in vivo fertilization. For the purpose of successful fertilization, spermatozoa are required to show a precise process in the exertion of their fertilizing ability. In this study, we indicated that pivotal regulators of the intracellular signaling and glucose metabolism are potential targets to suppress precocious fertilization-related events in the spermatozoa. In addition, we also suggested that defective phosphorylation at the tyrosine residues of acrosomal proteins is one of causal factors for unstable structure in the spermatozoa from subfertile male animals.