A Comprehensive Study on the Drug-Drug Interactions in Drug Metabolizing Enzyme CYP

细胞色素P450（CYP）在人体药物代谢中起着关键作用，CYP底物结合口袋中的药物相互作用常引起药物的不良反应。本研究通过对药物结合和代谢特性的全面研究，旨在揭示一组易发生药物相互作用的药物以及SNPs对药物相互作用的影响。我们可以揭示，药物在底物结合口袋中的方向可以用光谱法检测，CYP的活性位点结构受到两种药物同时结合的影响。

Cytochrome P450 (CYP) plays a key role in human drug metabolism, and drug-drug interactions in the substrate binding pocket of CYPs often induce unexpected adverse effects of drugs. In this study, drug binding and metabolizing properties of CYP were examined comprehensively, aiming at revealing a set of drugs susceptible to drug-drug interactions and effects of SNPs on the interactions. We could reveal that drug orientation in the substrate binding pocket can be detected spectroscopically, and that the active-site structure of CYPs is affected by the binding of two drugs simultaneously.