Role of heterocellular gap-junctional communication between cardiomyocytes and myofibroblasts in genesis of ventricular tachy arrhytymias

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This study addressed the possibility that myofibroblasts (MF), produced during healing phase of myocardial infarct, play important role(s) in fatal ventricular tachyarrhythmias. In scrape loading of the left ventricular wall, neurobiotin loaded into the cardiomyocytes (CM) propagated to the surrounding MF via Cx43. CM culture of neonate revealed slower conduction of the CM tissue co-cultured with MF in the opposite side of the filter membrane cup. Arrhythmogenic depolzizations were observed in CM layer when MFs were cultured in filter-membrane on the opposite side. Taken together, MF plays important role in arrhythmias during MI.