Neuroscientific studies on the effect of moxibustion on chronic diseases

艾灸对慢性病影响的神经科学研究

• 批准号: 20390200
• 负责人: USUDA Nobuteru
• 金额: $ 12.06万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390200/
• 关键词: 東洋医学; 施灸の脳科学

Subjective evidence of the brain reactions for moxibustion was attempted. Moxibustion treatment was done on rats, and measurements of brain functions based on neurotransmitter secretion by microdialysis; electrophysiological changes including EEG ; and gene expression analyses by DNA microarray, were performed. As all the reaction measured was very weak, high S/N ratio was required. Dopamine secretion, elevated gene expression, the elevation of body temperature, changes of hippocampal θwave in EEG, were shown in the experiments. As these are considered to affect brain functions including emotion, memory, etc, moxibustion may have possible curative effects on chronic diseases.

并试图从主观上证明艾灸引起的脑反应。对大鼠进行艾灸治疗，并通过微透析进行基于神经递质分泌的脑功能测量;包括EEG的电生理变化;以及通过DNA微阵列进行基因表达分析。由于所测量的所有反应都非常弱，因此需要高的S/N比。实验结果表明，脑缺血后多巴胺分泌增加，基因表达增加，体温升高，脑电图海马θ波改变。由于这些被认为影响大脑功能，包括情绪，记忆等，艾灸可能对慢性疾病有疗效。

项目成果

Novel therapeutic approach for Alzheimer's disease by removing amyloid beta protein from the brain with an extracorporeal removal system.

通过体外去除系统从大脑中去除淀粉样β蛋白，从而治疗阿尔茨海默病的新方法。

• 发表时间: 2010
• 期刊: J Artif Organs. 13
• 作者: Kawaguchi K;Kitaguchi N;Nakai S;Murakami K;Asakura K;Mutoh T;Fujita Y;Sugiyama S.
• 通讯作者: Sugiyama S.

Expression of Tumor Necrosis Factor Receptors on Granulocytes in Patients with Myeloperoxidase Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis

• DOI: 10.1159/000235242
• 发表时间: 2009-01-01
• 期刊: NEPHRON CLINICAL PRACTICE
• 作者: Hasegawa, Midori;Nishii, Chikako;Sugiyama, Satoshi
• 通讯作者: Sugiyama, Satoshi

Consortium for Alzheimer Disease. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.

阿尔茨海默病联盟。

• 发表时间: 2009
• 期刊: Genomics. 93
• 作者: Takei N;Higuchi S;Kuwano R.;他
• 通讯作者: 他

Effective detection of histochemical reaction products by phase contrast electron microscopy

通过相差电子显微镜有效检测组织化学反应产物

• 发表时间: 2009
• 作者: Usuda N;et al.
• 通讯作者: et al.

非晶質凍結状態細胞内超微小構造の位相差電子顕微鏡観察

非晶冷冻状态细胞内超微结构的相差电子显微镜观察

• 发表时间: 2008
• 作者: 臼田;信光
• 通讯作者: 信光