Translational research on intractable neuro-metabolic disorders

对顽固性神经代谢疾病如先天性疾病如肉碱载体缺乏症、柠檬素缺乏症、棘皮舞蹈病，以及多因子疾病如癌症恶病质、饮食失调、情绪障碍等进行转化研究。建立JVS小鼠和动物癌症恶病质和柠檬素缺乏症模型并进行病理分析。本研究创造了新的治疗方法，如乙酰肉碱、丙酮酸、胃促生长素激动剂和利坤适等，并应用于临床。

The translational research was conducted on intractable nuero-metablic disorders such as congenital diseases including carnitine carrier deficiency, citrin deficiency and chorea acantosis, and maltifactorial diseases including cancer cachexia, eating disorders and mood disorders. JVS mouse and animal models of cancer cachexia and citrin deficiency were created and used on pathological analysis. New treatment methods, such as acetylcarnitine, pyruvic acid, ghrelin agonist and Rikkunshito, were created or applied clinically from this research work.