Translational research on intractable neuro-metabolic disorders

难治性神经代谢疾病的转化研究

• 批准号: 20390199
• 负责人: INUI Akio
• 金额: $ 11.9万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390199/
• 关键词: 遺伝子; 医療・福祉; 神経医学; トランスレーショナルリサーチ; 臨床; 神経科学

The translational research was conducted on intractable nuero-metablic disorders such as congenital diseases including carnitine carrier deficiency, citrin deficiency and chorea acantosis, and maltifactorial diseases including cancer cachexia, eating disorders and mood disorders. JVS mouse and animal models of cancer cachexia and citrin deficiency were created and used on pathological analysis. New treatment methods, such as acetylcarnitine, pyruvic acid, ghrelin agonist and Rikkunshito, were created or applied clinically from this research work.

该转化研究针对难治性神经代谢障碍，如先天性疾病，包括肉毒碱载体缺乏症、柠檬酸缺乏症和舞蹈病棘突症，以及多因素疾病，包括癌症恶病质、饮食障碍和情绪障碍。建立JVS小鼠和癌症恶病质和柠檬酸缺乏的动物模型，并用于病理分析。新的治疗方法，如乙酰卡尼汀，阿托伐他汀，生长激素释放肽激动剂和Rikkunshito，是从这项研究工作中创建或应用于临床。

项目成果

Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats

• DOI: 10.3748/wjg.14.6318
• 发表时间: 2008-11-07
• 期刊: WORLD JOURNAL OF GASTROENTEROLOGY
• 影响因子: 4.3
• 作者: Fujimiya, Mineko;Asakawa, Akihiro;Inui, Akio
• 通讯作者: Inui, Akio

Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis(JVS)mice : Involvement of defective acyl-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus

缺乏肉碱的幼年内脏脂肪变性（JVS）小鼠对禁食的喂养反应失败：下丘脑中酰基生长素释放肽分泌缺陷和促肾上腺皮质激素释放因子信号增强的参与

• 发表时间: 2009
• 期刊: Biochimica et Biophysica Acta-Molecular Basis of Disease 1792
• 作者: Sakoguchi T;Horiuchi M;Asakawa A;Ushikai M;Yoshida G;Fujimiya M;Kato I;Nakazato M;Takeuchi T;Saheki T;Inui A.
• 通讯作者: Inui A.

悪液質改善剤

恶病质改善剂

• 发表时间: 2010

Neural control of the anorexia-chachexia syndrome.

厌食症-厌食症综合征的神经控制。

• 发表时间: 2008
• 期刊: Am J Physiol Endocrinol Metab 295(5)
• 作者: Laviano A;Inui A;Marks DL;Meguid MM;Pichard C;Rossi Fanneli F;Seelaender MC
• 通讯作者: Seelaender MC

悪液質のトランスレーショナルリサーチ

恶病质的转化研究

• 发表时间: 2009
• 作者: Nishimura-Sakurai S;et al;乾明夫
• 通讯作者: 乾明夫