Development of transgenic animals for the study of feeding behavior and stress response

最近在大脑和外周中发现了新的分子介质和调节摄食和体重的途径。通过基因靶向已经产生了过表达或缺乏这些介质的小鼠，对突变小鼠的观察揭示了每个元素在体重调节的稳态环中的作用。我们培育出神经肽Y过表达小鼠，表现出焦虑样行为（异型小鼠）和肥胖倾向（同型小鼠）。我们还开发了胰多肽过表达小鼠，其表现出与食物摄入减少和胃排空率相关的瘦表型。这些都是为了支持这项研究拨款而制作的例子。

Recently novel molecular mediators and regulatory pathways for feeding and body weight regulation have been identified in the brain and the periphery. Mice overexpressing or lacking these mediators have been produced by gene targeting, and observations on mutant mice have shed new light on the role of each element in the homeostatic loop of body weight regulation. We have developed neuropeptide Y overexpressing mouse which exhibited anxiety-like behavior (heteromouse) and obese tendency (homomouse). We have also developed pancreatic polypeptide overex-pressing mouse which exhibited thin phenotype associated with decreased food intake and gastric emptying rates. These are examples that were produced in support of this research grant.