Study for Molecular mechanism of cardiorenal connection.

许多临床发现证明心、肾疾病密切相互作用，但其分子机制尚不完全清楚。我们发现，肾功能不全时循环血浆可溶性Flt-1水平降低，而肾功能不全时PlGF/Flt-1系统相对激活，导致动脉粥样硬化恶化。我们还发现Klotho mRNA在糖尿病肾病的远端小管中表达减少，这增加了Klotho参与高钙尿症从而导致肾功能障碍动脉粥样硬化的可能性。

Many clinical findings proves the close interaction of the heart and kidney diseases, but its molecular mechanism is not fully understood. Here we show, that the circulating plasma level of soluble Flt-1 is reduced in renal dysfunction and that PlGF/Flt-1 system is relatively activated in renal dysfunction, leading the worsening of atherosclerosis. We also find Klotho mRNA expression is reduced in the distal tubules in diabetic nephropaty and raise possibility of Klotho is involved in hypercalciuria and thereby atherosclerosis in renal dysfunction.