Identifying a factor contributing to gender difference in familial dilated cardiomyopathy

确定导致家族性扩张型心肌病性别差异的因素

• 批准号: 25670393
• 负责人: SAITO Yoshihiko
• 金额: $ 2.41万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670393/
• 关键词: 循環器・高血圧; 性差; 心筋症

Gender difference is well known in cardiovascular disorder. Prevalence of ischemic heart disease is lower in female, or the age at risk of heart failure is higher in female. In this study, we tried to unveil the mechanism of gender difference in cardiovascular disease.At first, we analyzed gene mutation in patients with familial dilated cardiomyopathy, and found a mutation in a gene which codes inner nucleus membrane protein, lamin. Next, we focused on sex hormone, and found that androgen receptor accumulated in nucleus of cardiomyocyte only in those who had the mutation. Currently we're still continuing to seek the mechanism of gender difference by utilizing lamin knock out mice. We would like to contribute to the progression of cardiovascular field by studying this gender difference issue more in detail.

心血管疾病的性别差异是众所周知的。女性缺血性心脏病患病率较低，或女性心力衰竭风险年龄较高。本研究首先对家族性扩张型心肌病患者的基因突变进行分析，发现编码核内膜蛋白核纤层蛋白（lamin）的基因存在突变，并对该基因的突变位点进行了分析。接下来，我们关注性激素，发现雄激素受体仅在有突变的人中积聚在心肌细胞核中。目前我们仍在继续利用核纤层蛋白基因敲除小鼠来寻找性别差异的机制。我们希望通过更详细地研究这一性别差异问题，为心血管领域的发展做出贡献。

项目成果

Evaluation of epicardial and intra-myocardial fat in a patient with mitochondrial cardiomyopathy

线粒体心肌病患者心外膜和心肌内脂肪的评估

• 发表时间: 2013
• 期刊: Int J Cardiol
• 影响因子: 3.5
• 作者: Okayama S;Uemura S;Saito Y.
• 通讯作者: Saito Y.

Worsening of Renal Function after One Year, Not During Hospitalization, is Stronger Predictor of Prognosis in Patients with ADHF.

一年后（而非住院期间）肾功能恶化是 ADHF 患者预后的更强预测指标。

• 发表时间: 2013
• 作者: Ueda T;Kawakami R;et al.
• 通讯作者: et al.

Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study.

• DOI: 10.1186/1532-429x-15-87
• 发表时间: 2013-09-26
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
• 作者: Okayama S;Nakano T;Uemura S;Fujimoto S;Somekawa S;Watanabe M;Nakajima T;Saito Y
• 通讯作者: Saito Y

Uremic Toxin Aggravates Atherosclerosis by Suppression of Endothelial Soluble Flt-1 Production in CKD

尿毒症毒素通过抑制 CKD 中内皮可溶性 Flt-1 的产生而加重动脉粥样硬化

• 发表时间: 2013
• 作者: Takeda Y;Uemura S;Matsui M;Matsumoto T;Seno A;Okada S;Nishida T;Soeda T;Okayama S;Somekawa S;Watanabe M;Kawata H;Kawakami R;Saito Y.
• 通讯作者: Saito Y.

Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations

• DOI: 10.1093/cvr/cvt106
• 发表时间: 2013-08-01
• 期刊: CARDIOVASCULAR RESEARCH
• 影响因子: 10.8
• 作者: Arimura, Takuro;Onoue, Kenji;Kimura, Akinori
• 通讯作者: Kimura, Akinori