Functional analysis of the new three disease-susceptibility genes for essential hypertension

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We performed the genome-wide association analysis with using microsatellite markers for essential hypertension and reported the new candidate genes in 2007. For these three years, we studied the new three disease-susceptibility genes for essential hypertension. One of them is LPIN1 gene. The phenotype of the LPIN1 knockout mice showed the high blood pressure, but the mechanism of the lpin1-induced hypertension is still unknown. More works about the examination of the rest candidate genes are left. We were able to show the estimable result for the new candidate genes of essential hypertension, but it is left what we should do still more.