Molecular mechanism of adipose tissue remodeling and lipotoxicity

越来越多的证据表明，肥胖与慢性、低度炎症状态有关，炎症可能是肥胖导致代谢综合征的潜在机制。我们已经证明，脂肪细胞和巨噬细胞之间的相互作用可能会加重肥胖引起的脂肪组织炎症。在这项研究中，我们为肥大脂肪细胞和脂肪组织巨噬细胞炎症变化的新分子机制提供了证据，这可能会导致新的治疗策略来预防或治疗代谢综合征。

Evidence has accumulated indicating that obesity is associated with a state of chronic, low-grade inflammation, suggesting that inflammation may be a potential mechanism, whereby obesity leads to the metabolic syndrome. We have demonstrated that the crosstalk between adipocytes and macrophages may aggravate obesity-induced adipose tissue inflammation. In this study, we provided evidence on the novel molecular mechanisms underlying the inflammatory changes in hypertrophied adipocytes and adipose tissue macrophages, which may lead to novel therapeutic strategies to prevent or treat the metabolic syndrome.