Concept of Physiologic Inflammation and Its Functional Significance
Concept of Physiologic Inflammation and Its Functional Significance
批准号:
24659450
负责人:
OGAWA Yoshihiro
金额:
$2.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012 至 --
中文摘要
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英文摘要
The data of this study suggest that pro-inflammatory M1 macrophages infiltrated into adipose tissue of pregnant mice induce insulin resistance via increased adipocyte lipolysis, thereby resulting in stable supply of energy to fetus. Our data also suggest that transient and reversible physiologic inflammation of adipose tissue in pregnant mice plays an important role in homeostasis both dam and fetus.
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DOI:
10.4061/2011/720926
发表时间:
2011
期刊:
International journal of inflammation
影响因子:
2
作者:
[Itoh M, Suganami T, Hachiya R, Ogawa Y]
通讯作者:
Ogawa Y
日本人だから知っておきたい「異所性脂肪」の恐怖
日本人应该知道的“异位脂肪”恐惧症
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[大久保博史, 福嶋俊明, 新城尊徳, 西村英紀, 藤城緑, 櫛山暁史, 菊池貴子, 浅野知一郎, 小川佳宏]
通讯作者:
小川佳宏
東京医科歯科大学大学院医歯学総合研究科分子内分泌代謝学分野
东京医科齿科大学医学齿科研究生院分子内分泌代谢科
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.2337/dc12-0269
发表时间:
2012-12
期刊:
Diabetes care
影响因子:
16.2
作者:
[Satoh-Asahara N, Shimatsu A, Sasaki Y, Nakaoka H, Himeno A, Tochiya M, Kono S, Takaya T, Ono K, Wada H, Suganami T, Hasegawa K, Ogawa Y]
通讯作者:
Ogawa Y
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yamazaki H, Kojima N, Kato K, Hirose E, Iwasaki T, Mizui T, Takahashi H, Hanamura K, Roppongi RT, Koibuchi N, Sekino Y, Mori N, Shirao T., Ogawa Y]
通讯作者:
Ogawa Y
共 6 条
Molecular mechanism of tissue fibrosis and develpment of revolutionary anti-fibrotic therapy
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批准号:25670439
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
-
负责人:OGAWA Yoshihiro
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依托单位:
Identification of target genes for DNA methylation in skeletal muscle and its medical application
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批准号:23659468
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2011
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负责人:OGAWA Yoshihiro
-
依托单位:
Molecular Mechanism of Metabolic Memory via a DNA Methylation and Its Medical Application
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批准号:23390240
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.4万
-
财政年份:2011
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负责人:OGAWA Yoshihiro
-
依托单位:
Molecular mechanism of adipose tissue remodeling and lipotoxicity
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批准号:20390261
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.9万
-
财政年份:2008
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负责人:OGAWA Yoshihiro
-
依托单位:
Pathophysiologic and therapeutic implication of leptin as a pro-inflammatory cytokine
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批准号:17390268
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.66万
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财政年份:2005
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负责人:OGAWA Yoshihiro
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依托单位:
Molecular Medicine of Leptin Regulation of Energy Metabolism and Its Medical Application
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批准号:15390294
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.34万
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财政年份:2003
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负责人:OGAWA Yoshihiro
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依托单位:
Molecular medicine of adipocyte differentiation
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批准号:15081203
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$24.83万
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财政年份:2003
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负责人:OGAWA Yoshihiro
-
依托单位:
Molecular mechanism of leptin-induced increase in glucose and lipid metabolism
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批准号:13470225
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.09万
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财政年份:2001
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负责人:OGAWA Yoshihiro
-
依托单位:
Molecular mechanism of BDNF as a agent that circumvents leptin resistance
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批准号:13557089
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.77万
-
财政年份:2001
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负责人:OGAWA Yoshihiro
-
依托单位:
Physiologic and pathophysiologic role of C-type natriuretic peptide
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批准号:11470226
-
项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$9.15万
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财政年份:1999
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负责人:OGAWA Yoshihiro
-
依托单位:
Transcriptional regulation of leptin in adipocytes.
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批准号:09671054
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:1997
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负责人:OGAWA Yoshihiro
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依托单位: