Biologic significance of candidate genes in genomic alteration regions of lymphoidmalignancies

眼附件边缘带B细胞淋巴瘤（Ocular MALT淋巴瘤）具有6q23.3缺失的特征性特征，本研究小组发现候选基因为TNFAIP3/A20。在约31%的套细胞淋巴瘤和50%的ABC型弥漫性大b细胞淋巴瘤中也发现了这种缺失。敲除实验表明，基因的缺失导致NF-kappaB的激活。当该基因在EB病毒永生化b细胞中被敲除时，集落形成能力增强，提示该基因的敲除促进了b细胞淋巴瘤的发生。

Ocular adnexal marginal zone B cell lymphoma (Ocular MALT lymphoma) has been shown to possess characteristic 6q23.3 loss and the candidate gene was found to be TNFAIP3/A20 by our group. The loss was also found in about 31% of mantle cell lymphoma and 50% of ABC type diffuse large B-cell lymphoma. The knock-down experiment revealed that the loss of the gene leads to activation of NF-kappaB. When the gene was knock-down in EB virus immortalized B-cell, the colony formation ability was increased, suggesting that the loss contribute B-cell lymphomagenesis.