Biological role of genes at genetic alteration regions for proliferation and differentiation in hem

基因改变区域基因对下摆增殖和分化的生物学作用

• 批准号: 18390286
• 负责人: SETO Masao
• 金额: $ 11.23万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390286/
• 关键词: ATLL; T; NK lymphoma; PTCL-U; T細胞リンパ腫; マントル細胞リンパ腫; BIM; NK; T白血病・リンパ腫; 急性前骨髄急性白血病; アレイCGH; ゲノム異常

1. Adult T-cell leukemia/lymphoma : Array CGH analysis revealed that genome profiles of acute and lymphoma types are distinct, and suggested that ATLL genetic alterations after HTLV1 infection may play a role for oncogenesis of the two clinmically distinct disease subtypes. Further characterization of genomic regions and identification of responsible genes from these regions are warranted. This will reveal functional significance of these genes in cell profilferation and differentiations.2. T/NK leukemia/lymphoma : extranodal T/NK and Aggressive NK lymphomas were found to have distinct genetic alteration patterns although clinical manifestations and EBV involvement are similar.3. Peripheral T-cell lymphoma-unspecified(PTCL-U) : PTCL-U with multiple genomic alterations were found in about half of the cases and the pattern of genomic alterations are similar to that of ATLL lymphoma type. Histology also showed similarity in that they have peomorphic nuclear shape and CCR4 expression.4. B-cell lymphoma : We have identified BIM gene loss in mantle cell lymphoma(MCL) . BIM gene is known to regulate BCL2 function. We therefore examined significance of apoptotic gene family by expression profiling analysis and suggested that a poor prognosis group in the MCL exist. This needs to further confirmation.

1.成人T细胞白血病/淋巴瘤：阵列CGH分析显示，急性和淋巴瘤类型的基因组图谱是不同的，并表明HTLV 1感染后ATLL基因改变可能在两种临床不同疾病亚型的肿瘤发生中发挥作用。基因组区域的进一步表征和从这些区域鉴定负责基因是必要的。这将揭示这些基因在细胞增殖和分化中的功能意义. T/NK白血病/淋巴瘤：结性T/NK和侵袭性NK淋巴瘤虽然临床表现和EBV感染相似，但基因改变模式不同.外周T细胞淋巴瘤-非特异性（PTCL-U）：在大约一半的病例中发现了具有多个基因组改变的PTCL-U，并且基因组改变的模式与ATLL淋巴瘤类型相似。组织学也显示出相似之处，即细胞核形态和CCR 4表达。B细胞淋巴瘤：我们已经确定了套细胞淋巴瘤（MCL）中的BIM基因缺失。已知BIM基因调节BCL 2功能。因此，我们通过表达谱分析研究了凋亡基因家族的意义，并建议在MCL中存在预后不良组。这需要进一步确认。

项目成果

Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1.

AML1/RUNX1对茎和祖细胞植入的同工型特异性增强。

• DOI: 10.1371/journal.pmed.0040172
• 发表时间: 2007-05
• 期刊: PLoS medicine
• 影响因子: 15.8
• 作者: Tsuzuki S;Hong D;Gupta R;Matsuo K;Seto M;Enver T
• 通讯作者: Enver T

Comparison of PTCL-U and lymphoma-type ATLL in terms of genomic imbalance by using array CGH analysis.

使用阵列 CGH 分析比较 PTCL-U 和淋巴瘤型 ATLL 的基因组失衡。

• 发表时间: 2007
• 作者: Tsuzuki;S.;中川 雅夫
• 通讯作者: 中川 雅夫

Karnan S.,Tagawa,H.,Masao Seto:Ocular adnexal marginal zone B cell lymphoma showed distinct genomic profile.

Karnan S.，Takawa，H.，Masao Seto：眼附件边缘区 B 细胞淋巴瘤表现出独特的基因组谱。

• 发表时间: 2007
• 作者: Honma;K.
• 通讯作者: K.

Ocular adnexal marginal zone B cell lymphoma has characteristic deletion at chromosome band 6q23.3-24.1 whose target is TNFAIP3.

眼附件边缘区B细胞淋巴瘤在染色体带6q23.3-24.1处有特征性缺失，其靶点是TNFAIP3。

• 发表时间: 2007
• 作者: Honma;K.
• 通讯作者: K.

Array-based comparative genomic hybridization(array-CGH)法を用いた胃癌における網羅的な染色体構造異常の解析.

采用基于芯片的比较基因组杂交（array-CGH）方法对胃癌染色体结构异常进行综合分析。

• 发表时间: 2006
• 作者: Oshiro;A.;瀬戸 加大;都築 忍;横山 俊彦;内田 智久
• 通讯作者: 内田 智久