Pathological roles of a citrullinating enzyme PADI4 in rheumatoid arthritis

瓜氨酸酶 PADI4 在类风湿性关节炎中的病理作用

• 批准号: 20390280
• 负责人: YAMAMOTO Kazuhiko
• 金额: $ 11.98万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390280/
• 关键词: 免疫学; ゲノム; 内科; 遺伝子

We have previously identified rheumatoid arthritis susceptibility polymorphisms in PADI4. This enzyme converts arginine residues to citrullines and anti-citrullinated peptide antibodies are the most specific autoantibodies in the disease. In order to understand the pathological mechanisms, we have generated and analyzed arthritis in PADI4 knock out mice.

我们以前已经确定了类风湿性关节炎易感性多态性PADI4。这种酶将精氨酸残基转化为瓜氨酸，抗瓜氨酸肽抗体是该疾病中最特异的自身抗体。为了理解病理机制，我们已经在PADI 4敲除小鼠中产生并分析了关节炎。

项目成果

Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.

• DOI: 10.1371/journal.pgen.1002067
• 发表时间: 2011-06
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Okada Y;Hirota T;Kamatani Y;Takahashi A;Ohmiya H;Kumasaka N;Higasa K;Yamaguchi-Kabata Y;Hosono N;Nalls MA;Chen MH;van Rooij FJ;Smith AV;Tanaka T;Couper DJ;Zakai NA;Ferrucci L;Longo DL;Hernandez DG;Witteman JC;Harris TB;O'Donnell CJ;Ganesh SK;Matsuda K;Tsunoda T;Tanaka T;Kubo M;Nakamura Y;Tamari M;Yamamoto K;Kamatani N
• 通讯作者: Kamatani N

PADI4 polymorphism predisposes male smokers to rheumatoid arthritis

• DOI: 10.1136/ard.2010.130526
• 发表时间: 2011-03-01
• 期刊: ANNALS OF THE RHEUMATIC DISEASES
• 影响因子: 27.4
• 作者: Kochi, Yuta;Thabet, Mohamed M.;Yamamoto, Kazuhiko
• 通讯作者: Yamamoto, Kazuhiko

PAD14 polymorphism predisposes male smokers to rheumatoid arthrilis.

PAD14 多态性使男性吸烟者易患类风湿性关节炎。

• 发表时间: 2011
• 期刊: Ann Rheum Dis
• 影响因子: 27.4
• 作者: Kochi Y;Thabet MM;Suzuki A;Okada Y;Daha NA;Toes REM;Huizinga TWJ;Myouzen K;Kubo M;Yamada R;Nakamura Y;Yamamoto K
• 通讯作者: Yamamoto K

Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice.

• DOI: 10.4049/jimmunol.181.8.5264
• 发表时间: 2008-10-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Okamoto A;Fujio K;van Rooijen N;Tsuno NH;Takahashi K;Tsurui H;Hirose S;Elkon KB;Yamamoto K
• 通讯作者: Yamamoto K

The Association of a Nonsynonymous Single-Nucleotide Polymorphism in TNFAIP3 With Systemic Lupus Erythematosus and Rheumatoid Arthritis in the Japanese Population

• DOI: 10.1002/art.27190
• 发表时间: 2010-02-01
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Shimane, Kenichi;Kochi, Yuta;Yamamoto, Kazuhiko
• 通讯作者: Yamamoto, Kazuhiko