Innovation of novel treatment and fetal therapy for ichthyosis

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In the present project, in order to innovate a novel therapy for ichhthyosis, we made a normal human ABCA12 gene construct, and performed transfection experiments of the construct into the cultured keratinocytes from ichthyosis patients and ABCA12-disrupted mice(ichthyosis model mice). We reconstructed ichthyosis lesions from the transfected keratinocytes and evaluated treatment efficacy of transfected ABCA12 gene constructs. In addition, we performed treatment experiments to fetuses of ABCA12-disrupted mice. From the results, we obtained clues to establish novel effective treatment against congenital ichthyosis.