Elucidation of roles of lipid mediators in the epidermis to innovate novel therapeutic strategies for keratinization disorders
Elucidation of roles of lipid mediators in the epidermis to innovate novel therapeutic strategies for keratinization disorders
批准号:
15H04887
负责人:
AKIYAMA Masashi
金额:
$11.32万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2015
资助国家:
日本
项目状态:
已结题
起止时间:
2015-04-01 至 2018-03-31
中文摘要
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英文摘要
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Deficient stratum corneum intercellular lipid in a Japanese patient with lamellar ichthyosis by a homozygous deletion mutation in SDR9C7.
一名日本板层状鱼鳞病患者因 SDR9C7 纯合缺失突变导致角质层细胞间脂质缺陷。
DOI:
10.1111/bjd.15315
发表时间:
2017
期刊:
Br J Dermatol
影响因子:
--
作者:
[Takeichi T, Nomura T, Takama H, Kono M, Sugiura K, Watanabe D, Shimizu H, Simpson MA, McGrath JA, Akiyama M.]
通讯作者:
Akiyama M.
St John’s Institute of Dermatology(英国)
圣约翰皮肤病研究所(英国)
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
教育講演:皮膚のバリア機能を担う分子と構造(かたち)
教育讲座:负责皮肤屏障功能的分子和结构
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Takeichi T, Togawa Y, Taniguchi R, Okuno Y, Kono M, Matsue H, Sugiura K, Akiyama M., 秋山真志]
通讯作者:
秋山真志
シンポジウム1 皮膚難病克服への挑戦:魚鱗癬・魚鱗癬症候群の病態解明と克服への挑戦
研讨会1:克服顽固性皮肤病的挑战:阐明鱼鳞病/鱼鳞病综合征的病理学和克服鱼鳞病的挑战
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Kono M, Fukai K, Shimizu N, Nagao J, Takeichi T, Tsuruta D, Sugiura K, Akiyama M., 秋山真志]
通讯作者:
秋山真志
DOI:
10.1038/s41598-018-30757-3
发表时间:
2018-08-27
期刊:
Scientific reports
影响因子:
4.6
作者:
[Taki T, Takeichi T, Sugiura K, Akiyama M]
通讯作者:
Akiyama M
共 13 条
Regulation of NETs formation by VWF and ADAMTS13 binding to neutrophil Siglecs
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批准号:19K08829
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2019
-
负责人:AKIYAMA Masashi
-
依托单位:
Elucidation of pathogenic mechanisms of ichthyosis due to epidermal lipid abnormalities and development of novel therapeutic agents
-
批准号:18H02832
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.15万
-
财政年份:2018
-
负责人:AKIYAMA Masashi
-
依托单位:
Analysis of generation mechanisms of somatic revertant mutations and development of their control methods aiming at new cell medicine strategy
-
批准号:18K19540
-
项目类别:Grant-in-Aid for Challenging Research (Exploratory)
-
资助金额:$4.08万
-
财政年份:2018
-
负责人:AKIYAMA Masashi
-
依托单位:
Elucidation of novel pathomechanisms due to defects in remote enhancers and chromatin domain TADs in genodermatosis
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批准号:16K15547
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.16万
-
财政年份:2016
-
负责人:AKIYAMA Masashi
-
依托单位:
Empirical study of gene therapy applicable to genetic diseases due to variable mutations, based on introduction of confining mutations
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批准号:15K15415
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2015
-
负责人:AKIYAMA Masashi
-
依托单位:
Elucidation of pathogenesis and development of novel therapy of chilblain lupus on the basis of an exonuclease enzyme
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批准号:24659526
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2012
-
负责人:AKIYAMA Masashi
-
依托单位:
Crystal structure analysis for the pathogenesis of thrombosis
-
批准号:23570155
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.49万
-
财政年份:2011
-
负责人:AKIYAMA Masashi
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依托单位:
Innovation of novel treatments for various phenotypes of ichthyosis by restoration of ABCA12 lipid transporter gene expression
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批准号:23249058
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.95万
-
财政年份:2011
-
负责人:AKIYAMA Masashi
-
依托单位:
Molecular mechanism of TSLP production in keratinocytes in atopic dermatitis
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批准号:23659546
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2011
-
负责人:AKIYAMA Masashi
-
依托单位:
Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.
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批准号:20570120
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2008
-
负责人:AKIYAMA Masashi
-
依托单位:
Innovation of novel treatment and fetal therapy for ichthyosis
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批准号:20390304
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.9万
-
财政年份:2008
-
负责人:AKIYAMA Masashi
-
依托单位:
Development of a new strategy for gene therapy of autosomal recessive congenital ichthyosis by gene transfer to the bulge stem cells
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批准号:16390312
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.28万
-
财政年份:2004
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负责人:AKIYAMA Masashi
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依托单位:
Studies on roles of malformation of the cornified cell envelope in phathogenesis of severe ichthyoses
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批准号:12670839
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2000
-
负责人:AKIYAMA Masashi
-
依托单位:
海外基金